The main purpose of this study is to determine if oxycodone and naltrexone combination
capsules (ALO-02) have the potential to be abused when they are crushed and snorted.
Drug Liking: Area Under Effect Curve (AUE) From 0-1 HourDrug Liking: Area Under Effect Curve (AUE) From 0-8 Hours
Drug Liking: Area Under Effect Curve (AUE) From 0-24 Hours
High: Area Under Effect Curve (AUE) From 0-1 Hour
High: Area Under Effect Curve (AUE) From 0-8 Hours
High: Area Under Effect Curve (AUE) From 0-24 Hours
Take Drug Again: Peak Effect (Emax)
Take Drug Again: Mean Effect (Emean)
Overall Drug Liking: Peak Effect (Emax)
Overall Drug Liking: Mean Effect (Emean)
Any Drug Effects: Area Under Effect Curve (AUE) From 0-1 Hour
Any Drug Effects: Area Under Effect Curve (AUE) From 0-2 Hours
Any Drug Effects: Area Under Effect Curve (AUE) From 0-8 Hours
Any Drug Effects: Area Under Effect Curve (AUE) From 0-24 Hours
Good Drug Effects: Area Under Effect Curve (AUE) From 0-1 Hour
Good Drug Effects: Area Under Effect Curve (AUE) From 0-2 Hours
Good Drug Effects: Area Under Effect Curve (AUE) From 0-8 Hours
Good Drug Effects: Area Under Effect Curve (AUE) From 0-24 Hours
Bad Drug Effects: Area Under Effect Curve (AUE) From 0-1 Hour
Bad Drug Effects: Area Under Effect Curve (AUE) From 0-2 Hours
Bad Drug Effects: Area Under Effect Curve (AUE) From 0-8 Hours
Bad Drug Effects: Area Under Effect Curve (AUE) From 0-24 Hours
Feel Sick: Area Under Effect Curve (AUE) From 0-1 Hour
Feel Sick: Area Under Effect Curve (AUE) From 0-2 Hours
Feel Sick: Area Under Effect Curve (AUE) From 0-8 Hours
Feel Sick: Area Under Effect Curve (AUE) From 0-24 Hours
Nausea: Area Under Effect Curve (AUE) From 0-1 Hour
Nausea: Area Under Effect Curve (AUE) From 0-2 Hours
Nausea: Area Under Effect Curve (AUE) From 0-8 Hours
Nausea: Area Under Effect Curve (AUE) From 0-24 Hours
Sleepy: Area Under Effect Curve (AUE) From 0-1 Hour
Sleepy: Area Under Effect Curve (AUE) From 0-2 Hours
Sleepy: Area Under Effect Curve (AUE) From 0-8 Hour
Sleepy: Area Under Effect Curve (AUE) From 0-24 Hour
Dizzy: Area Under Effect Curve (AUE) From 0-1 Hour
Dizzy: Area Under Effect Curve (AUE) From 0-2 Hours
Dizzy: Area Under Effect Curve (AUE) From 0-8 Hours
Dizzy: Area Under Effect Curve (AUE) From 0-24 Hours
Any Drug Effects: Peak Effect (Emax)
Good Drug Effects: Peak Effect (Emax)
Bad Drug Effects: Peak Effect (Emax)
Feel Sick: Peak Effect (Emax)
Nausea: Peak Effect (Emax)
Sleepy: Peak Effect (Emax)
Dizzy: Peak Effect (Emax)
Subject Rating Scale for Nasal Effects: Area Under Effect Curve (AUE) From 0-1 Hour for "burning"
Subject Rating Scale for Nasal Effects: Area Under Effect Curve (AUE) From 0-2 Hours for "burning"
Subject Rating Scale for Nasal Effects: Peak Effect (Emax) for "burning"
Subject Rating Scale for Nasal Effects: Time to Maximum (Peak) Effect (TEmax) for "burning"
Percentage of dose (drug powder) insufflated
Pupillometry: Area Under Effect Curve (AUE) From 0-1 Hour
Pupillometry: Area Under Effect Curve (AUE) From 0-2 Hours
Pupillometry: Area Under Effect Curve (AUE) From 0-8 Hours
Pupillometry: Area Under Effect Curve (AUE) From 0-24 Hours
Pupillometry: Peak Effect (Emax)
Pupillometry: Time to Maximum (Peak) Effect (TEmax)
Drug Liking: Time to Maximum (Peak) Effect (TEmax)
High: Time to Maximum (Peak) Effect (TEmax)
Any Drug Effects: Time to Maximum (Peak) Effect (TEmax)
Good Drug Effects: Time to Maximum (Peak) Effect (TEmax)
Bad Drug Effects: Time to Maximum (Peak) Effect (TEmax)
Sleepy: Time to Maximum (Peak) Effect (TEmax)
Dizzy: Time to Maximum (Peak) Effect (TEmax)
Nausea: Time to Maximum (Peak) Effect (TEmax)
Feel Sick: Time to Maximum (Peak) Effect (TEmax)
Maximum Observed Plasma Concentration (Cmax) of Oxycodone
Maximum Observed Plasma Concentration (Cmax) of Oxymorphone
Maximum Observed Plasma Concentration (Cmax) of Noroxycodone
Maximum Observed Plasma Concentration (Cmax) of Naltrexone
Maximum Observed Plasma Concentration (Cmax) of 6-beta-naltrexol
Time to Reach Maximum Observed Plasma Concentration (Tmax) of Oxycodone
Time to Reach Maximum Observed Plasma Concentration (Tmax) of Oxymorphone
Time to Reach Maximum Observed Plasma Concentration (Tmax) of Noroxycodone
Time to Reach Maximum Observed Plasma Concentration (Tmax) of Naltrexone
Time to Reach Maximum Observed Plasma Concentration (Tmax) of 6-beta-naltrexol
Plasma Decay Half-Life (t1/2) of Oxycodone
Plasma Decay Half-Life (t1/2) of Oxymorphone
Plasma Decay Half-Life (t1/2) of Noroxycodone
Plasma Decay Half-Life (t1/2) of Naltrexone
Plasma Decay Half-Life (t1/2) of 6-beta-naltrexol
Area Under the Oxycodone Concentration-Time Curve (AUC0-1h)
Area Under the Oxymorphone Concentration-Time Curve (AUC0-1h)
Area Under the Noroxycodone Concentration-Time Curve (AUC0-1h)
Area Under the Naltrexone Concentration-Time Curve (AUC0-1h)
Area Under the 6-beta-naltrexol Concentration-Time Curve (AUC0-1h)
Area Under the Oxycodone Concentration-Time Curve (AUC0-2h)
Area Under the Oxymorphone Concentration-Time Curve (AUC0-2h)
Area Under the Noroxycodone Concentration-Time Curve (AUC0-2h)
Area Under the Naltrexone Concentration-Time Curve (AUC0-2h)
Area Under the 6-beta-naltrexol Concentration-Time Curve (AUC0-2h)
Area Under the Oxycodone Concentration-Time Curve (AUC0-8h)
Area Under the Oxymorphone Concentration-Time Curve (AUC0-8h)
Area Under the Noroxycodone Concentration-Time Curve (AUC0-8h)
Area Under the Naltrexone Concentration-Time Curve (AUC0-8h)
Area Under the 6-beta-naltrexol Concentration-Time Curve (AUC0-8h)
Area Under the Curve From Time Zero to Last Quantifiable Oxycodone Concentration (AUClast)
Area Under the Curve From Time Zero to Last Quantifiable Oxymorphone Concentration (AUClast)
Area Under the Curve From Time Zero to Last Quantifiable Noroxycodone Concentration (AUClast)
Area Under the Curve From Time Zero to Last Quantifiable Naltrexone Concentration (AUClast)
Area Under the Curve From Time Zero to Last Quantifiable 6-beta-naltrexol Concentration (AUClast)
Minimum age: 18 Years.
Maximum age: 55 Years.
Gender(s): Both.