Clinical Comparison of Efficacy and Safety of Two Teriparatide Formulations: Osteofortil and Forteo
Information source: Bio Sidus SA
ClinicalTrials.gov processed this data on August 20, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Postmenopausal Osteoporosis With Pathological Fracture
Intervention: Teriparatide (rDNA origin) (Drug)
Phase: Phase 4
Status: Active, not recruiting
Sponsored by: Bio Sidus SA
Summary
The primary objective of this study is to compare efficacy and safety of two formulations of
teriparatide 20 mcg/day plus calcium and vitamin D in postmenopausal women with
osteoporosis.
Clinical Details
Official title: Comparación de la Eficacia y Seguridad clínicas de Osteofortil Respecto de Forteo
Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Primary outcome: Change from baseline in Bone mineral Density at 6 months.
Secondary outcome: Change from baseline in P1NP, Osteocalcin, C-terminal cross-linked telopeptide of type I collagen levels at 3 and 6 months
Eligibility
Minimum age: 50 Years.
Maximum age: 81 Years.
Gender(s): Female.
Criteria:
Inclusion Criteria:
I. Female.
II. Age greater than or equal to 50 and less than 81 years.
III. Last menstrual period at least one year prior to signing the informed consent.
IV. Osteoporosis. Defined by the presence of:
BMD by DEXA with a T-score of - 2. 5 or lower on lumbar spine or T-score at the lumbar
spine, femoral neck or total hip - 2. 0 or below, together with one or more vertebral
fractures documented by lateral spine radiographs.
V. Have signed the informed consent
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Exclusion Criteria:
I Bone alkaline phosphatase in the blood above the normal limit without any explanation.
II. Liver disease (AST or ALT> 2 x ULN). III. Renal disease (serum creatinine> 2. 0 mg /
dl) and / or creatinine clearance <30 ml / min IV. Hypercalcemia ([Ca]> 10. 5 mg / dL).
Patients with elevated PTH in the presence of albumin-corrected calcium within normal
values can be re-evaluated.
V. Elevated blood PTH ([PTH]> 65 pg / ml) Patients with elevated PTH in the presence of
albumin-corrected calcium within normal values can be re-evaluated.
VI. • Deficiency of vitamin D (25-OH vitamin D <16 ng / ml) or excess vitamin D (above 80
ng / ml blood). Patients who did not meet the inclusion criteria for vitamin D may receive
a supplement (vitamin D) and be re-evaluated.
VII. • Anemia (hematocrit <32%).
VIII. • History of cancer (except basal cell carcinoma) or radiotherapy.
IX. Severe cardiopulmonary disease, including coronary heart disease: unstable angina,
heart failure class III or IV or any other condition that the investigator believes may
prevent participation safely and complete the protocol procedures.
X. Major psychiatric disease that in the opinion of the investigator, would prevent to
give properinformed consent or complete the study procedures.
XI. Excessive alcohol or substance abuse that in the opinion of the investigator prevents
giving informed consent or complete proper protocol procedures.
XII. Congenital or acquired bone disease, other than osteoporosis (including osteomalacia,
hyperparathyroidism or Paget's disease)
XIII. Regarding the history of ingestion of oral bisphosphonates: After assessment of
adequate adherence (compliance greater than 75%), if the patient received six months of
treatment, she should have a bisphosphonate-free period of six months. If she took more
than six months, the bisphosphonate-free period must be 12 months.
XIV. Current or within the last 3 months before study entry estrogen use, selective
estrogen receptor modulators use or calcitonin use in therapeutic doses.
XV. Current use of systemic corticosteroids (oral or parenteral) for more than 14 days in
the last 6 months. Vaginal estrogen and isoflavones are permitted .
XVI. Current or previous use of teriparatide, other PTH analogues as patches or
injectables, strontium, fluorine or any intravenous bisphosphonate therapeutic dose, XVII.
Known hypersensitivity to pharmaceuticals derived from bacterial cells. XVIII.
Hypersensitivity to teriparatide or to any of its excipients. XIX. Nephrolithiasis or
urolithiasis in activity, according to the investigator opinion in the 5 years prior to
randomization.
XX. Inflammatory bowel disease, malabsorption syndrome or any sign of intestinal calcium
malabsorption
XXI. Treatment with androgens or anabolic steroids in the 6 months prior to randomization.
XXII. Any medical condition that in the investigator opinion would contraindicate
treatment with an investigational drug.
XXIII. Treatment with coumarin and indandione derivatives in the 3 months prior to
randomization or treatment with heparins (at doses> 10,000 U / day) for more than 30 days
in the 6 months prior to randomization.
XXIV. Treatment with any other drug known to affect bone metabolism, in therapeutic
doses,in the 6 months prior to randomization.
XXV. Treatment with an investigational drug during the month prior to randomization. -
Locations and Contacts
Instituto de Investigaciones Metabolicas, Ciudad Autonoma de Buenos Aires, Argentina
Additional Information
Starting date: June 2013
Last updated: January 21, 2014
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