Clinical Significance of Smear or Culture Positive for Candida Spp. From Sputum Three Times a Week
Information source: Capital Medical University
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Pulmonary Candidiasis
Intervention: fluconazole 400md/d (Drug)
Phase: N/A
Status: Active, not recruiting
Sponsored by: Capital Medical University Official(s) and/or principal investigator(s):
Bin Cao, Doctor, Principal Investigator, Affiliation: Beijing Chaoyang Hospital, Affiliate of Capital Medical University
Summary
The definition of pulmonary candidiasis is still unclear. In China, isolation of candida spp.
form sputum twice or three times a week has been regarded as the microbiological evidence of
pulmonary candidiasis. We hypothesize that patients who present respiratory symptoms and lung
infiltrates together with smear of culture positive for candida spp. from sputum three times
a week can not be diagnosed as pulmonary candidiasis.
Clinical Details
Study design: Natural History, Longitudinal, Defined Population, Prospective Study
Eligibility
Minimum age: 14 Years.
Maximum age: 85 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- 85ys>age>14ys
- APACHE II<25
- Lung infiltrates together with at least one of the following symptoms: cough, sputum,
dyspnea with or without fever
- smear or culture positive for candida spp. from sputum
Exclusion Criteria:
- pregnancy
- hypersensitivity to fluconazole
- isolated candida was non-sensitive to fluconazole
- severe liver or renal diseases who can not tolerate fluconazole treatment
- with at least one of the following high risk factors: organ transplantation,
neutropenia>10ds, long term glucocorticoids therapy(equal to prednisone 30mg/d longer
than 2 weeks), immunosuppressive therapy within 30ds, AIDS
- with one of the microbiological evidence: isolation of candida spp. from blood or other
kinds of sterile site(not including urine), filamentous fungi isolated from sputum or
BALF, cryptococcus isolated from sputum or CSF, galactomannan antigen positive twice
for blood
- probable or possible pulmonary aspergillosis
- definite oral or esophageal candidiasis
Locations and Contacts
Beijing Chaoyang Hospital,Affiliate of Capital Medical University, Beijing 100020, China
Additional Information
Starting date: September 2007
Ending date: December 2008
Last updated: October 1, 2007
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