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An Attempt to Reduce Community-Acquired Methicillin-Resistant Staphylococcus Aureus (MRSA) Infection in Soldiers

Information source: Brooke Army Medical Center
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Community-Acquired MRSA Infections; Abscesses; Cellulitis; Folliculitis

Intervention: Mupirocin (drug) (Drug)

Phase: N/A

Status: Completed

Sponsored by: Brooke Army Medical Center

Official(s) and/or principal investigator(s):
Michael W Ellis, MD, Principal Investigator, Affiliation: Brooke Army Medical Center

Summary

The main purpose of this study is to determine if applying mupirocin into soldiers noses who are colonized with methicillin-resistant Staphylococcus aureus (MRSA) will reduce infections in them and their cohort of fellow soldiers.

Clinical Details

Official title: An Attempt to Reduce Community-Acquired Methicillin-Resistant Staphylococcus Aureus Infection in Soldiers: a Controlled Trial

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Prevention

Primary outcome: Soft tissue infections in subjects who received the study medication and soft tissue infections in the study cohorts.

Secondary outcome: Changes in S. aureus carriage rates (including MRSA).

Detailed description: Community-acquired MRSA infections are increasingly common in the community and in particular among certain groups of which soldiers are one. Many researchers and clinicians have postulated that one method to prevent infections is to selectively eradicate CA-MRSA in those who are colonized with the pathogen. The two main purposes of the study are: to determine if selective CA-MRSA eradication in subjects reduces infections in the CA-MRSA colonized individual; and to determine if selective CA-MRSA eradication in subjects reduces infections in the study cohort. Other information concerning CA-MRSA includes: prevalence, risk factors, and virulence data. The population will be soldiers enrolled in the combat medic training class at Ft. Sam Houston. We will enroll approximately 3000 soldiers over a two year period. After informed written consent, we will culture their anterior nares nares and administer questionnaires at the beginning and at the end of the study, following them prospectively for infections. The follow-up period will be 16 weeks. For those with CA-MRSA in their nares, they will be randomized (by cohort) to receive either 5 days of mupirocin or placebo.

Eligibility

Minimum age: 17 Years. Maximum age: 60 Years. Gender(s): Both.

Criteria:

Inclusion Criteria: Soldiers enrolled into the combat medic course at Ft. Sam Houston, TX.

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Exclusion Criteria: Allergy to mupirocin.

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Locations and Contacts

Brooke Army Medical Center, Ft. Sam Houston, Texas 78234, United States
Additional Information

Related publications:

Ellis MW, Hospenthal DR, Dooley DP, Gray PJ, Murray CK. Natural history of community-acquired methicillin-resistant Staphylococcus aureus colonization and infection in soldiers. Clin Infect Dis. 2004 Oct 1;39(7):971-9. Epub 2004 Sep 2.

Starting date: January 2005
Last updated: February 13, 2006

Page last updated: August 23, 2015

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