Antibiotic Resistant Helicobacter Pylori in Rajavithi Hospital
Information source: Rajavithi Hospital
Information obtained from ClinicalTrials.gov on October 19, 2009
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Dyspepsia
Intervention: gastroscopic examination (Procedure)
Phase: Phase 3
Status: Recruiting
Sponsored by: Rajavithi Hospital Official(s) and/or principal investigator(s):
Piyathida Harnsoomboon, MD, Principal Investigator, Affiliation: Rajavithi Hospital
Summary
Peptic ulcer disease is the most common gastrointestinal disease. Antibiotic resistant
Helicobacter pylori is a major problem worldwide. The gold standard for Helicobacter pylori
eradication is composed of Proton-pump inhibitor/Ranitidine bismuth citrate + Amoxycillin +
Metronidazole /Clarithromycin. In Thailand, clarithromycin resistant strains increased and
led to treatment failure. Data on file at Rajavithi Hospital showed that metronidazole
resistant H. pylori was about 50% and Clarithromycin resistant strains accounted for 8%.
This molecular genetic study will be performed in patients presenting with dyspepsia, who
had an indication for gastroscopic examination, to explore the incidence of antibiotic
resistant Helicobacter pylori in Rajavithi Hospital, Thailand.
Clinical Details
Official title: Antibiotic Resistance Helicobacter Pylori and Clarithromycin Resistance Mutation in Helicobacter Pylori in Rajavithi Hospital
Study design: Case Control, Prospective
Primary outcome: Incidence of H. pylori Clarithromycin resistance gene
Secondary outcome: Characteristic of H. pylori clarithromycin resistant gene mutation
Detailed description:
Genetic and Biomolecular factors determining clarithromycin resistance will be
characterized.
Eligibility
Minimum age: 15 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- male or female with dyspepsia
- age > 15 years
- fulfil indication for gastroscopic examination
- able to give informed consent
Exclusion Criteria:
- contraindication for gastroscopic examination and biopsy
Locations and Contacts
Rajavithi Hospital, Ratchathewi, Bangkok 10400, Thailand; Recruiting
Piyathida Harnsomboonrana, M.D., Phone: 6618423854, Email: pboontee@yahoo.com
Additional Information
Starting date: June 2006
Ending date: December 2008
Last updated: August 2, 2008
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