KETOR: Effects of Peri Operative Administration of Ketamine on Long Term Post Thoracotomy Pain
Information source: Assistance Publique - Hôpitaux de Paris
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Ketamine; Chronic Post Thoracotomy Pain; Thoracotomy; Pain; Neuralgia
Intervention: Ketamine (or placebo : isotonic saline solution) (Drug)
Phase: Phase 3
Status: Completed
Sponsored by: Assistance Publique - Hôpitaux de Paris Official(s) and/or principal investigator(s):
Thierry GUENOUN, MD, Principal Investigator, Affiliation: Assistance Publique - Hôpitaux de Paris
Summary
We assessed the effects of the N Methyl aspartate receptor antagonist Ketamine on long-term
post thoracotomy pain. We hypothesized that ketamine could prevent supersensitization of the
central nervous system involved in this chronic neuropathic pain.
Clinical Details
Official title: Effects of Peri Operative Administration of Ketamine on Long Term Post Thoracotomy Pain
Study design: Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy Study
Primary outcome: Long term (2 months) post thoracotomy pain was assessed using a french equivalent of the Mc Gill Pain score and pain area measurements in both groups
Secondary outcome: Analogic pain scores at rest and after coughing
Detailed description:
In this clinical, randomized prospective study, peri operative administration of ketamine was
compared to placebo on long term post thoracotomy pain after a 2 months follow up period.
Eligibility
Minimum age: 80 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Patients eligible for thoracotomy or pneumectomy
Exclusion Criteria:
-
Locations and Contacts
Georges Pompidou European Hospital, PARIS, Ile De France 75015, France
Additional Information
Related publications: Frappier J, Guenoun T, Journois D, Philippe H, Aka E, Cadi P, Silleran-Chassany J, Safran D. Airway management using the intubating laryngeal mask airway for the morbidly obese patient. Anesth Analg. 2003 May;96(5):1510-5, table of contents.
Starting date: January 2003
Ending date: May 2005
Last updated: April 12, 2006
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