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Evaluation of the Effects of Oxygen Therapy and Enalapril for Diabetic Macular Ischemia

Information source: Shahid Beheshti Medical University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Diabetic Macular Ischemia

Intervention: enalapril (Drug); oxygen (Other); placebo (Drug)

Phase: Phase 1

Status: Recruiting

Sponsored by: Shahid Beheshti Medical University

Overall contact:
Masoud Soheilian, MD, Phone: +982122585952, Email: labbafi@hotmail.com

Summary

In this study, patients were divided into 3 group with 35 cases including: 1. oxygen 2. enalapril 3. control. In the beginning of the study, best corrected visual acuity (BCVA), uncorrected visual acuity (UCVA), and optical coherence tomography (OCT) were measured. Patients in the oxygen group were given oxygen 10 lit/min 1 hour twice a day at the first month, once a day at the second month and every other day at the third month. In the enalapril group, patients were given enalapril 5 mg every night and placebo was given for the patients in third group. At the end of first month the patients' vision was checked again and at the the end of the third month the first physical examinations were performed. In the first group, arterial blood gas (ABG) was taken before and after oxygen therapy as well.

Clinical Details

Official title: Evaluation of the Effects of Oxygen Therapy and Enalapril for Diabetic Macular Ischemia

Study design: N/A

Eligibility

Minimum age: N/A. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Patients diagnosed with diabetic macular ischemia

Exclusion Criteria:

- HTN > 1140/90 or HTN controlled by ACE inhibitors

- FBS > 200

- Severe anemia, COPD, cataract, HRPDR and diffuse macular edema

Locations and Contacts

Masoud Soheilian, MD, Phone: +982122585952, Email: labbafi@hotmail.com

Ophthalmic Research Center, Tehran 166666, Iran, Islamic Republic of; Recruiting
Masoud Soheilian, MD, Phone: +98 21 22585952, Email: labbafi@hotmail.com
Additional Information


Last updated: May 11, 2009

Page last updated: August 23, 2015

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