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Combination Pill of Losartan Potassium and Hydrochlorothiazide for Improvement of Medication Compliance Trial

Information source: Kyushu University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Hypertension

Intervention: Combination pill of losartan and hydrochlorothiazide (Drug)

Phase: Phase 3

Status: Completed

Sponsored by: Kyushu University

Official(s) and/or principal investigator(s):
Kiyoshi Matsumura, MD PhD, Principal Investigator, Affiliation: Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University

Summary

The purpose of the study is to determine whether combination pill of losartan potassium and hydrochlorothiazide will improve medication compliance among patients with high blood pressure.

Clinical Details

Official title: A Randomized Trial to Establish the Effects of Combination Pill of Losartan Potassium and Hydrochlorothiazide on Medication Compliance Among Patients With High Blood Pressure.

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Medication compliance

Secondary outcome:

Blood pressure

cost of blood pressure lowering drugs

serious adverse events

adverse events

blood test

Detailed description: Despite clear evidence that blood pressure lowering treatment is beneficial for reduction of cardiovascular disease, blood pressure levels are not adequately controlled in many hypertensive patients. More intensive blood pressure lowering treatment is required to achieve maximum reduction of cardiovascular disease. Combination pills of blood pressure lowering drugs could be a safe and effective strategy to achieve blood pressure target but there is no randomized evidence that established the beneficial effects of combination pills of blood pressure lowering drugs. The purpose of the study is to determine whether combination pill of losartan potassium and hydrochlorothiazide will improve medication compliance among patients with high blood pressure.

Eligibility

Minimum age: 20 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Aged 20 years or above

- Hypertension defined as blood pressure levels of >/=140/90mmHg or current use of

blood pressure lowering drugs

- Able to commence combination therapy of angiotensin receptor antagonists and

diuretics Exclusion Criteria:

- Blood pressure measurements of >/=200/120mmHg

- Previous serious adverse events due to angiotensin receptor antagonists or diuretics

- Known or possible pregnancy

- Known severe liver dysfunction

- Known severe kidney disease

- Known contraindication to angiotensin receptor antagonists or diuretics

- Taking >/=4 tablets except for angiotensin receptor antagonists

- ACE inhibitors, thiazide or thiazide-like diuretics in the morning

- Current participation in another clinical trial

- A high likelihood that the patient is not suitable for the study treatment

Locations and Contacts

Department of Medicine and Clinical Science, Kyushu University, Fukuoka City, Fukuoka 812-8582, Japan
Additional Information

Starting date: June 2008
Last updated: March 4, 2011

Page last updated: August 23, 2015

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