Effect of Tamsulosin vs Prazosin in Treatment of Female Voiding Dysfunction
Information source: Tabriz University
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Neurogenic Bladder
Intervention: tamsolusin (Drug); prazosin (Drug)
Phase: Phase 1/Phase 2
Status: Active, not recruiting
Sponsored by: Tabriz University Official(s) and/or principal investigator(s):
SAKINEH hajebrahimi, MD, Study Director, Affiliation: Urology department ofTabriz University of Medical Sciences
Summary
The purpose of this study is to determine whether Tamsolusin or Prazosin are effective in
the treatment of female voiding dysfunction(BOO)
Clinical Details
Official title: Effect of Tamsulosin vs Prazosin in Treatment of Female Voiding Dysfunction
Study design: Treatment, Randomized, Double Blind (Subject, Outcomes Assessor), Active Control, Parallel Assignment, Safety/Efficacy Study
Primary outcome: patient symptoms improvement(Standard questionare)
Secondary outcome: Urodynamics parameters improvement
Detailed description:
Voiding dysfunction is not uncommon in Tabriz. About 20% of patients in female urology clinic
of Tabriz university of medical sciences sufered from some degrees of voiding dysfunction
(due to bladder imparement or bladder outlet obstruction).There is limited information about
medical treatment of those patients. On the other hand alpha adrenergic blockers are the
first choice medication in BENIGN PROSTATIC HYPERPLASIA. There is some new facts about
destribution of alpha adrenergic blockers in female pelvic floor. The purpose of this study is
to comparision whether Tamsolusin 0. 4/daily or Prazosin 1 mg/daily are effective in the
treatment of female voiding dysfunction(BOO)
Eligibility
Minimum age: 20 Years.
Maximum age: 70 Years.
Gender(s): Female.
Criteria:
Inclusion Criteria:
- Healthy females with voiding difficulty with MFR<12 and post void residual urine>50cc
Exclusion Criteria:
- History of pelvic floor surgury during last 3 month
- Any contraindication for Tamsolusin or prazosin
Locations and Contacts
Additional Information
Starting date: July 2005
Ending date: March 2008
Last updated: January 26, 2008
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