The Proton Pump Inhibitor (PPI) Test for the Extraesophageal Manifestation of GERD
Information source: Samsung Medical Center
Information obtained from ClinicalTrials.gov on October 19, 2009
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Gastroesophageal Reflux Disease
Intervention: Proton pump inhibitor (rabeprazole) (Drug)
Phase: N/A
Status: Recruiting
Sponsored by: Samsung Medical Center Official(s) and/or principal investigator(s):
Poong-Lyul Rhee, MD. Ph.D, Principal Investigator, Affiliation: Samsung Medical Center, Sungkyunkwan University School of Medicine
Overall contact:
Tae ggon Kim, Phone: +82-2-3410-2975, Email: tggo.kim@samsung.com
Summary
PPI test;empirical trial with high-dose proton-pump inhibitors (PPIs) has been shown to be a
sensitive tool for diagnosing patients with GERD. However, this diagnostic strategy has not
been well established in patients with extraesophageal manifestation of GERD. In this study,
we aim to see the relevance of PPI test in diagnosing GERD in patients with extraesophageal
symptoms.
Clinical Details
Official title: Clinical Usefulness of Proton Pump Inhibitor Test for Identifying Gastroesophageal Reflux Disease in Patients With Extraesophageal Symptoms
Study design: Diagnostic, Open Label, Parallel Assignment
Primary outcome: Symptom responders after PPI trials
Eligibility
Minimum age: 20 Years.
Maximum age: 75 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Patients with extraesophageal manifestation symptoms of GERD
Exclusion Criteria:
- laryngeal, pharyngeal, liver, lung, renal, or hematological disorders
- a history of gastrointestinal surgery, and a history of connective tissue disorders.
- patients with duodenal or gastric ulcers as well as other significant lesions, such
as gastric cancer, esophageal cancer, or subepithelial tumors more than 1 cm observed
on the upper endoscopy
Locations and Contacts
Tae ggon Kim, Phone: +82-2-3410-2975, Email: tggo.kim@samsung.com
Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Gangnam-gu 135-710, Korea, Republic of; Recruiting
Poong Lyul Rhee, M.D., Ph.D, Phone: +82-2-3410-3409, Email: plrhee@skku.edu
Poong-Lyul Rhee, M.D., Ph.D., Principal Investigator
Additional Information
Starting date: March 2006
Last updated: October 4, 2007
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