Candesartan Effectiveness Study in Pro-BNP
Information source: AstraZeneca
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Hypertension; Left Ventricular Hypertrophy
Intervention: Candesartan (Drug); Felodipine (Drug); Study manual adherence (Procedure)
Phase: Phase 4
Status: Active, not recruiting
Sponsored by: AstraZeneca Official(s) and/or principal investigator(s):
JeeWoong Son, MD, Study Director, Affiliation: AstraZeneca
Summary
The purpose of this study is to investigate effect of candesartan based therapy on percent
change of B type natriuretic peptides(BNP) level in the subjects with hypertension and left
ventricular hypertrophy.
Clinical Details
Official title: A Multicenter, Non-Comparative, Phase IV Study to Evaluate the Effect of Candesartan Based Therapy in the Percent Change of proBNP Level After 24 Week Treatment in the Patients With Hypertension With Left Ventricular Hypertrophy
Study design: Treatment, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Efficacy Study
Primary outcome: To investigate the percent change of B type natriuretic peptides(BNP) level in the subjects with hypertension and left ventricular hypertrophy treated with candesartan
Secondary outcome: LVH regressionChange of systolic and diastolic blood pressure Percent change of proBNP in patients treated with candesartan only vs candesartan+felodipine Change of mean ambulatory blood pressure Change of collagen markers
Eligibility
Minimum age: 18 Years.
Maximum age: 75 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Hypertension with diastolic blood pressure within 95-115mmHg or/and systolic blood
pressure within 160-200 mmHg
- Patients diagnosed as left ventricular hypertrophy by electrocardiogram
Exclusion Criteria:
- Secondary hypertension
- History of myocardial infarction
- Stroke within the previous 6 months
Locations and Contacts
Research Site, DaeGu, Korea, Republic of
Research Site, BuSan, Korea, Republic of
Research Site, KwangJu, Korea, Republic of
Research Site, JeonJu, Korea, Republic of
Research Site, DaeJeon, Korea, Republic of
Research Site, CheonAn, Korea, Republic of
Research Site, CheongJu, Korea, Republic of
Research Site, Chunbuk, Korea, Republic of
Research Site, GYUNGSANGNAMDO, Korea, Republic of
Research Site, PUSAN, Korea, Republic of
Research Site, ULSAN, Korea, Republic of
Additional Information
Starting date: June 2006
Ending date: December 2008
Last updated: February 2, 2008
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