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Dose of Norepinephrine and the Concentration of L-Lactate in the Rectum and Stomach in Patients With Septic Shock.

Information source: Herlev Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Septic Shock

Intervention: Changing dose of norepinephrine and blood pressure (Drug)

Phase: N/A

Status: Completed

Sponsored by: Herlev Hospital

Official(s) and/or principal investigator(s):
Anders Perner, MD,PhD, Study Chair, Affiliation: Dept. of Anaesthesia and Intensive Care, Herlev University Hospital, DK-2730 Herlev

Summary

Norepinephrine is a drug used to increase blood pressure in patients with life-threatening infection. However, norepinephrine may limit the bloodflow to the gut, thereby causing relative lack of oxygen to the cells. This leads to increased formation of lactic acid. This study examines whether increasing the dose of norepinephrine leads to higher concentrations of lactic acid in the rectum and stomach in patients with life-threatening infection.

Clinical Details

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind, Primary Purpose: Treatment

Primary outcome: L-lactate concentration in the rectum and stomach.

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Septic shock

- NE-dose > 0. 1 microg/kg/min

- CI > 3. 0 l/min/m2

Exclusion Criteria:

- Age < 18, unable to obtain informed consent from relatives

- Untreated hypertension

- Pregnancy

- Pathology in the rectum or stomach

- Limitation of therapy

Locations and Contacts

Dept. of Intensive Care, Herlev University Hospital, Herlev 2730, Denmark
Additional Information

Starting date: October 2004
Last updated: September 19, 2006

Page last updated: August 23, 2015

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