Impact of MK-0954A on Uric Acid in the Management of Hypertension (MK-0954A-366)
Information source: Merck Sharp & Dohme Corp.
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Hypertension
Phase: N/A
Status: Completed
Sponsored by: Merck Sharp & Dohme Corp.
Summary
This was a retrospective, chart review, observational study to assess the effect of MK-0954A
(losartan potassium 50 mg + hydrochlorothiazide 12. 5 mg [Hyzaar(R)]) treatment for a period
of at least three months on serum uric acid levels.
Clinical Details
Official title: A Retrospective Survey to Evaluate the Impact of Hyzaar on Uric Acid in the Management of Hypertensive Patients in Normal Practice
Study design: Observational Model: Cohort, Time Perspective: Retrospective
Primary outcome: Serum Uric Acid (SUA) Level
Secondary outcome: The Percentage of Patients With HyperuricemiaDiastolic Blood Pressure (DBP) Systolic Blood Pressure (SBP)
Eligibility
Minimum age: 20 Years.
Maximum age: 75 Years.
Gender(s): Both.
Criteria:
Inclusion criteria:
- Participant was >20 years and <75 years of age on the index date (i. e., the date of
initiating MK-0954A therapy)
- Diagnosed with hypertension and had received MK-0954A 50/12. 5 mg for at least 3
months
- Had at least one serum uric acid measurements at baseline and one at 3 months after
using MK-0954A 50/12. 5 mg
- Had the following records documented in the chart during the data collection period:
- medical history and co-morbidities (if available)
- sitting blood pressure, serum uric acid, lipid profile test results before and
after using MK-0954A 50/12. 5 mg
- serum electrolytes, serum creatinine, and pre-meal sugar (if available)
- prescription information of all antihypertensive regimens
Exclusion criteria:
- Had been treated with diuretic or angiotensin-receptor blockers (ARBs) 2 weeks before
initiated treatment with MK-0954A 50/12. 5 mg
- Serum creatinine >2 mg/dL
Locations and Contacts
Additional Information
Starting date: November 2008
Last updated: December 3, 2014
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