Compromised Microcirculation in Women With Polycystic Ovary Syndrome
Information source: Yale University
Information obtained from ClinicalTrials.gov on February 07, 2013
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Polycystic Ovary Syndrome
Intervention: ganirelix acetate (Drug); methyl testosterone (Drug)
Phase: N/A
Status: Recruiting
Sponsored by: Yale University Official(s) and/or principal investigator(s):
Nina Stachenfeld, PhD, Principal Investigator, Affiliation: John B. Pierce Laboratory
Overall contact:
Nina Stachenfeld, PhD, Phone: 203 562-9901, Ext: 219, Email: nstach@jbpierce.org
Summary
The scientific aims of the study are to determine how peripheral microcirculatory
responsiveness is altered in obese women with Polycystic Ovary Syndrome (PCOS) during local
heating and to determine the mechanism for testosterone effects on peripheral
microcirculatory responsiveness in women with PCOS.
Clinical Details
Official title: Compromised Microcirculation in Women With Polycystic Ovary Syndrome
Study design: Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science
Primary outcome: Skin blood flow and cutaneous vascular conductance
Detailed description:
In these studies, we propose to use the skin as a relatively non-invasive model to examine
cardiovascular and endothelial function in obese women with and without PCOS. Data have
indicated an important role for testosterone in influencing the peripheral microcirculation.
While testosterone can lead to vasodilation in the peripheral microcirculation in both men
and in women without PCOS, testosterone appears to induce vasoconstriction in women with
PCOS. The differential response between women with and without PCOS, and between men and
women may be the result of differential ET-1 actions in the vessel, and regulated by the
receptor subtype is involved in these actions.
Eligibility
Minimum age: 18 Years.
Maximum age: 35 Years.
Gender(s): Female.
Criteria:
Inclusion Criteria:
- Obese women (18-35) years with and without PCOS
Exclusion Criteria:
- Conditions that would preclude safe use of hormones
Locations and Contacts
Nina Stachenfeld, PhD, Phone: 203 562-9901, Ext: 219, Email: nstach@jbpierce.org
John B. Pierce Laboratory, New Haven, Connecticut 06520, United States; Recruiting
Additional Information
Starting date: February 2008
Last updated: August 5, 2011
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