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A Comparison of Lorazepam and Diazepam in the Treatment of Alcohol Withdrawal

Information source: Stanford University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Alcohol Withdrawal

Intervention: Lorazepam (Drug); Diazepam (Drug)

Phase: N/A

Status: Completed

Sponsored by: Stanford University

Official(s) and/or principal investigator(s):
Jose R Maldonado, MD, Principal Investigator, Affiliation: Stanford University

Summary

The purpose of this study is to compare the efficacy of two commonly used medications in the treatment of alcohol withdrawal, diazepam and lorazepam.

Clinical Details

Official title: A Comparison of Lorazepam and Diazepam in the Treatment of Alcohol Withdrawal

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: The primary outcome measures include serial measures of vital signs and scores on the Clinical Institute Withdrawal Assessment for Alcohol-Revised scale (CIWA-Ar), a widely used scale that monitors alcohol withdrawal symptoms.

Secondary outcome: Secondary outcome measures include total benzodiazepine use.

Detailed description: Despite the frequent use of benzodiazepines for the treatment of alcohol withdrawal, studies comparing the efficacy of long and short half-life benzodiazepines in the treatment of alcohol withdrawal have shown mixed results. Due to the conflicting nature of published reports, clinicians have no clear indication as to which type of agent is preferable. The purpose of this study is to compare the efficacy of two commonly accepted medications in the treatment of alcohol withdrawal, diazepam and lorazepam, which are long and short half-life benzodiazepines, respectively.

Eligibility

Minimum age: 19 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Clinical diagnosis of alcohol withdrawal

- History of alcohol use within 24 hours

- Ability to consent to participate in the study

Exclusion Criteria:

- Unwillingness to participate in the study

- Active abuse of other CNS depressants

- Acute intoxication with a CNS activating agent

- Severe hepatic dysfunction

- Pregnancy

- History of dementia

Locations and Contacts

Palo Alto Veterans Affairs Hospital System, Palo Alto, California 94304, United States

Stanford Hospital and Clinics, Stanford, California 94305, United States

Additional Information

Starting date: May 2003
Last updated: August 29, 2007

Page last updated: August 23, 2015

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