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Effect of Ticagrelor vs. Dipyridamole on Adenosine Uptake

Information source: Vanderbilt University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Coronary Artery Disease

Intervention: Adenosine (Drug)

Phase: Phase 2

Status: Active, not recruiting

Sponsored by: Vanderbilt University

Official(s) and/or principal investigator(s):
Italo Biaggioni, MD, Principal Investigator, Affiliation: Vanderbilt University


The investigators are trying to determine if a single dose of Ticagrelor will increase delivery of intraarterially-infused adenosine into the forearm interstitium, consistent with adenosine reuptake blockade.

Clinical Details

Official title: Ticagrelor and Adenosine Uptake. Phase II Study Comparing the Effects of Ticagrelor vs Dipyridamole on Adenosine Uptake

Study design: Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject)

Primary outcome: Interstitial levels of adenosine

Detailed description: The investigators will compare adenosine interstitial levels using a parallel design study with three groups of subjects. Forearm interstitial adenosine levels will be measured at baseline and after intrabrachial infusion of adenosine at two doses. Subjects will then randomly receive Ticagrelor 180 mg, Dipyridamole 200 mg, or placebo. Two hours later the investigators will repeat the dialysate collections at baseline and after adenosine infusions.


Minimum age: 18 Years. Maximum age: 65 Years. Gender(s): Both.


Inclusion Criteria: 1. Subjects will be healthy volunteers, without significant pulmonary, cardiovascular gastrointestinal, hematological or renal diseases 2. Not taking any regular medications 3. Able to provide signed consent prior to study participation. Exclusion Criteria: 1. History of asthma 2. Pregnancy 3. Exposure to an investigational drug in the last 2 months. 4. Known hypersensitivity to study medications

Locations and Contacts

Autonomic Dysfunction Center, Nashville, Tennessee 37232, United States
Additional Information

Starting date: August 2012
Last updated: July 13, 2015

Page last updated: August 23, 2015

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