TRAUMA HELP: Healing and Analgesia With Propranolol
Information source: University of North Carolina, Chapel Hill
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Trauma
Intervention: Propranolol (Drug); Propranolol ER (Drug); Sugar pills (Drug)
Phase: Phase 2
Sponsored by: University of North Carolina, Chapel Hill
Official(s) and/or principal investigator(s):
Samuel M McLean, MD MPH, Principal Investigator, Affiliation: UNC Chapel Hill School of Medicine
The purpose of this study is to determine whether propranolol can decrease pain symptoms in
a common subset of patients admitted to a trauma center after injury.
Official title: Phase IIB Study: TRAUMA HELP: Healing and Analgesia With Propranolol
Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Primary outcome: Daily average pain score (0-10 numeric rating pain score recorded daily from patient) after study drug initiation.
The main purpose of this pilot study is to investigate Propranolol's utility in the trauma
population. Specifically, to see if it reduces pain scores post-injury.
Minimum age: 18 Years.
Maximum age: 60 Years.
- at least one fracture
- ages 18-60 yrs
- pain score >= 4
- speak and read English
- gunshot, stab wound, or assault
- psychotic, suicidal, or homicidal
- hepatic, kidney failure
- clinically unstable or intubated at time of recruitment
- propranolol use within the last 6 months
- significant bradycardia
- cancer (except basal cell)
- peripheral vascular disease
- heart block > 1 degree
- congestive heart failure
Locations and Contacts
University of North Carolina Trauma Center, Chapel Hill, North Carolina 27599, United States
Starting date: October 2009
Last updated: December 7, 2011