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Metabolism of the Insecticide Permethrin

Information source: University of California, Davis
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Pharmacokinetics; Metabolism

Intervention: permethrin insecticide (Other)

Phase: N/A

Status: Completed

Sponsored by: University of California, Davis

Official(s) and/or principal investigator(s):
Bruce D Hammock, PhD, Principal Investigator, Affiliation: University of California, Davis

Summary

Military personnel are exposed to the insecticide permethrin when using the DOD Insect Repellent System. A urinary metabolite of permethrin that is in high abundance and is relatively stable may be an ideal biomarker of exposure to this pesticide. Monitoring such a biomarker can prevent over-exposure. The objectives are to identify the most abundant human urinary metabolite following dermal exposure; to utilize this information to develop rapid laboratory-based and field portable methods to monitor the degree of an individual's exposure to permethrin.

Clinical Details

Official title: CCRC:Identification and Development of Biological Markers of Human Exposure to the Insecticide Permethrin

Study design: Basic Science, Open Label, Single Group Assignment, Pharmacokinetics Study

Primary outcome: Concentration of individual metabolites in urine

Secondary outcome:

total carbon-14 in serum

Total carbon-14 in saliva

Total carbon-14 in urine samples

Detailed description: Permethrin is applied to the forearm of the subject and remains for 8 hours. The exposed area is then washed with soap and water several times. 24 hour urine samples are collected at daily intervals for 192 hours. Blood and saliva samples are taken at pre-dose, 1, 3, 6, 9 12, 24, 48, 72, 96, 120, 144, 168 and 192 hours. Subjects must return to the clinic daily to drop off urine collections and have blood and saliva samples taken.

Eligibility

Minimum age: 18 Years. Maximum age: 50 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- self-report healthy adult men and premenopausal women

Exclusion Criteria:

- unusual alcohol, drug, cigarette use for last 3 years

- unusual exercise program for last 3 years

- under the care of a physician for a disease

- participated in any radioactive drug study

- pregnant

- lactating

- people who rely more on their arm due to illness or injury

- people with neurological or musculoskeletal diseases

- use of permethrin in the last 6 months

- people who apply pesticides as their primary occupation

Locations and Contacts

CTSC Research Center, Mather, California 95655, United States
Additional Information

Starting date: February 2006
Ending date: November 2007
Last updated: December 11, 2007

Page last updated: June 20, 2008

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