High-Resolution Ultrasound Imaging of the Retina and Choroid for Detection on Age Related Macular Degeneration
Information source: Weill Medical College of Cornell University
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Age Related Macular Degeneration
Intervention: Ultrasound examination (Procedure)
Phase: N/A
Status: Completed
Sponsored by: Weill Medical College of Cornell University Official(s) and/or principal investigator(s):
Ronald H Silverman, PhD, Principal Investigator, Affiliation: Weill Cornell Medical College
D. Jackson Coleman, MD, Study Chair, Affiliation: Weill Cornell Medical College - New York Presbyterian Hospital
Summary
The macula is the site of central vision within the retina. The retina is oxygenated by the
underlying choroid. These tissues are less than 1 mm thick in total. While optical
techniques can reveal much about the structure of the retina, ultrasound allows imaging of
the choroid and deeper tissues. This study will investigate use of high frequency (20 MHz)
ultrasound for imaging of the retina and choroid in patients with age-related macular
degeneration, a prime cause of blindness. The investigation will involve use of novel
post-processing methodologies to achieve maximum resolution of the fine tissue structures
involved in this disease.
Clinical Details
Official title: High-Resolution Ultrasound Imaging of the Retina and Choroid
Study design: Case-Only, Prospective
Detailed description:
Age-related macular degeneration (AMD), a condition affecting over 40% of individuals 70
years or age or more, causes progressive loss of central vision. Photocoagulation has long
been used to slow the progress of AMD, but new vision-preserving methods are currently under
investigation. Because destroyed photoreceptors are permanently lost, early management is
essential for preservation of vision. The aim of this project will be to study AMD using a
suite of new high-resolution ultrasound imaging techniques that have been developed.
Specifically, high-resolution ultrasound will be used to generate images of the retina and
choroid, including perfusion measurements using slow-flow methods developed by our research
group. Ultrasound studies will be performed in conjunction with optical coherence tomography
(OCT) imaging in a series of patients and age-matched control subjects with the aim of
determining if choroidal thickness and/or perfusion might be used as an early indicator of
AMD and thus aid in patient management.
We will study 20 subjects diagnosed with AMD. We will attempt to have an approximately equal
number of subjects with wet and dry forms of AMD. A control group consisting of 20 non-AMD
age-matched subjects will also be recruited. Ultrasound scan sequences will consist of B-mode
images of the macula and surrounding tissues.
Eligibility
Minimum age: 45 Years.
Maximum age: 90 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
Age related macular degeneration age matched control
Exclusion Criteria:
none
Locations and Contacts
Weill Cornell Medical College, New York, New York 10021, United States
Additional Information
Bioacoustic Research Facility @ Weill Medical College of Cornell University Home Page
Related publications: Silverman RH. Ultrasound versus AC OCT. J Cataract Refract Surg. 2005 Aug;31(8):1475; author reply 1475-7. No abstract available. Coleman DJ, Silverman RH, Chabi A, Rondeau MJ, Shung KK, Cannata J, Lincoff H. High-resolution ultrasonic imaging of the posterior segment. Ophthalmology. 2004 Jul;111(7):1344-51.
Starting date: July 2005
Ending date: June 2006
Last updated: March 4, 2008
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