Cytochrome P450 2E1 and Iron Overload
Information source: Rennes University Hospital
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Insulin Resistance; Iron Overload
Intervention: venesection therapy (Procedure)
Phase: N/A
Status: Completed
Sponsored by: Rennes University Hospital Official(s) and/or principal investigator(s):
Jean-Michel Reymann, PhD, Study Chair, Affiliation: CHU Rennes
Fabrice Lainé, MD, Principal Investigator, Affiliation: CHU Rennes
Summary
The aim of the study is to determine, in patients presenting with insulin resistance and
hepatic iron overload, the effects of venesection therapy on cytochrome P450 2E1 activity by
comparing the rates of metabolization of chlorzoxazone before and after venesection.
Clinical Details
Official title: Cytochrome P450 2E1 and Iron Overload
Study design: Treatment, Randomized, Open Label, Uncontrolled, Parallel Assignment
Primary outcome: chlorzoxazone metabolization rate before and after venesection
Eligibility
Minimum age: 18 Years.
Maximum age: 70 Years.
Gender(s): Male.
Criteria:
Inclusion Criteria:
- Male patients aged from 18 to 70 years
- Hepatic iron overload measured by magnetic resonance imaging [MRI] (> 36 µmol/g)
- Related to insulin resistance
Exclusion Criteria:
- Excess alcohol consumption
- Female gender
Locations and Contacts
Unité d'Investigation Clinique - Hôpital Pontchaillou, Rennes 35033, France
Additional Information
Starting date: September 2003
Ending date: December 2005
Last updated: September 18, 2006
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