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The Effect of Vitamin B3 on Substrate Metabolism, Insulin Sensitivity, and Body Composition in Obese Men

Information source: Aarhus University Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Obese

Intervention: Nicotinamide riboside (NIAGEN TM, ChromaDex, CA, USA ) (Dietary Supplement); Placebo (Dietary Supplement)

Phase: N/A

Status: Not yet recruiting

Sponsored by: Aarhus University Hospital

Official(s) and/or principal investigator(s):
Britt Christensen, Phd, Post doc, Principal Investigator, Affiliation: The Novo Nordisk Foundation Center for Basic Metabolic Research, Integrative Physiology, University of Copenhagen

Overall contact:
Britt Christensen, Phd, Post doc, Phone: +45 31194819, Email: britt.christensen@ki.au.dk

Summary

In animals, treatment with vitamin B3 improved insulin sensitivity and substrate metabolism. It is currently not know if vitamin B3 has the same positive effects in humans. In the current study the effect of a 3 month treatment with vitamin B3 on insulin sensitivity and substrate metabolism in obese men will be investigated.

Clinical Details

Official title: The Effect of Nicotinamide Ribose (NR) on Substrate Metabolism, Insulin Sensitivity, and Body Composition in Obese Men - a Randomized, Placebo Controlled Clinical Trial

Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: Insulin sensitivity

Secondary outcome:

Substrate metabolism

body composition

Activation of satellite cells

lipid accumulation in liver and skeletal muscle tissue

glucose turnover

insulin signalling in skeletal muscle and adipose tissue biopsies

Palmitate turnover

Eligibility

Minimum age: 18 Years. Maximum age: 70 Years. Gender(s): Male.

Criteria:

Inclusion Criteria:

- written signed consent

- male

- BMI>30 kg/(m2)

- wge: 18-70

- no medication

- non-smoker

Exclusion Criteria:

- endocrine disease

- other severe disease

- high daily activity level (>30 min / day)

Locations and Contacts

Britt Christensen, Phd, Post doc, Phone: +45 31194819, Email: britt.christensen@ki.au.dk

Medical Research Laboratories, Aarhus University Hospital, Aarhus 8000, Denmark; Not yet recruiting
Britt Christensen, Phd, Post doc, Phone: +45 31194819, Email: britt.christensen@clin.au.dk
Additional Information

Starting date: January 2016
Last updated: June 22, 2015

Page last updated: August 23, 2015

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