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Study of Amiloride on Vascular Phenotypes in Young Adults With Prehypertension

Information source: Georgia Health Sciences University
Information obtained from ClinicalTrials.gov on February 07, 2013
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Prehypertension

Intervention: Amiloride (Drug)

Phase: Phase 4

Status: Recruiting

Sponsored by: Georgia Health Sciences University

Overall contact:
Samip J Parikh, MBBS, MPH, Phone: 7067211764, Email: sparikh@georgiahealth.edu

Summary

Primary Specific Aim: To test the hypothesis that amiloride will improve vascular health of young adults with prehypertension.

Clinical Details

Study design: Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Vascular phenotypes

Eligibility

Minimum age: 18 Years. Maximum age: 35 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Prehypertensive: Having systolic BP between 120 to 139 mmHg and/or diastolic BP

between 80 to 89 mmHg during screening visit. BP will be measured manually tree times at 10 minutes interval after subjects sit quietly for at least 5 minutes in a chair. The average of last two BP measurements will be taken into consideration.

- Male or female of Caucasian or African-American origin.

- No history of any major past and current medical illness (such as diabetes, renal

disease, liver disease etc.)

- Not taking any medication that affects blood pressure.

Exclusion Criteria:

- HbA1C > 7. 0 % during screening visit.

- Serum potassium > 5. 5 mEq/L during screening and/or any testing visit due to risk of

developing hyperkalemia.

- Serum creatinine > 1. 5 mg/100 ml and/or creatinine clearance < 50 ml/min* (Glomerular

Filtration Rate Estimate by Abbreviated MDRD Study Equation)35 during screening and/or any testing visit due to risk of developing renal dysfunction.

- Female having positive pregnancy test during screening and/or any testing visit.

Locations and Contacts

Samip J Parikh, MBBS, MPH, Phone: 7067211764, Email: sparikh@georgiahealth.edu

Georgia Prevention Institute, Augusta, Georgia 30912, United States; Recruiting
Yanbin Dong, MD, PhD, Principal Investigator
Additional Information

Starting date: September 2010
Last updated: October 22, 2012

Page last updated: February 07, 2013

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