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Effect of Succinylcholine on Patients Using Statins

Information source: Outcomes Research Consortium
Information obtained from ClinicalTrials.gov on October 19, 2009
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Pain

Intervention: Succinylcholine (Drug)

Phase: N/A

Status: Recruiting

Sponsored by: Outcomes Research Consortium

Official(s) and/or principal investigator(s):
Daniel I Sessler, MD, Study Chair, Affiliation: Cleveland Clinic

Overall contact:
Gretchen Upton, BA, Phone: 216-444-3289, Email: uptong@ccf.org

Summary

Based on available mechanistic and clinical information, the investigators propose a nonrandomized study to evaluate the effect of succinylcholine in patients taking statins. The investigators' purpose is to evaluate the effect of succinylcholine on patients taking statins. Patients scheduled to undergo elective surgery (other then orthopedic, spinal, vascular or muscle) with planned endotracheal intubation will be approached regarding participation in the trial. Design of the study is complex because there is no way to randomize patients to statins or no statins and also no way to take them off the statins prior surgery. So statin use will not be randomized; confounding factors will be accounted for by stratification (every 10 years of age from 40-80 and gender) and statistical adjustment. The investigators propose to test the hypothesis that succinylcholine administration increases plasma myglobulin concentration more in patients who are on statins compared to patients who do not.

Clinical Details

Official title: Effect of Succinylcholine on Patients Using Statins

Study design: Case Control, Cross-Sectional

Primary outcome: plasma myglobulin concentration

Secondary outcome:

muscle pain

serum potassium concentration

plasma CK concentration

urine myoglobin and onset plus duration of succinylcholine block

Eligibility

Minimum age: 40 Years. Maximum age: 80 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Scheduled for elective surgery not involving orthopedic procedure, muscle and spinal

surgery

- ASA Physical Status 1-3

Exclusion Criteria:

- History of liver failure

- History of renal failure

- History of neuromuscular disease

- Increased intraocular pressure

- Recent major burn

- Multiple trauma

- Susceptibility to or family history of malignant hyperthermia

Locations and Contacts

Gretchen Upton, BA, Phone: 216-444-3289, Email: uptong@ccf.org

Cleveland Clinic Foundation, Cleveland, Ohio 44195, United States; Recruiting
Alparslan Turan, MD, Principal Investigator
Additional Information

Starting date: September 2009
Ending date: September 2010
Last updated: September 29, 2009

Page last updated: October 19, 2009

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