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Effect of Succinylcholine on Patients Using Statins

Information source: Outcomes Research Consortium
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Pain

Intervention: Succinylcholine (Drug)

Phase: N/A

Status: Completed

Sponsored by: Outcomes Research Consortium

Official(s) and/or principal investigator(s):
Daniel I Sessler, MD, Study Chair, Affiliation: The Cleveland Clinic


Based on available mechanistic and clinical information, the investigators propose a nonrandomized study to evaluate the effect of succinylcholine in patients taking statins. The investigators' purpose is to evaluate the effect of succinylcholine on patients taking statins. Patients scheduled to undergo elective surgery (other then orthopedic, spinal, vascular or muscle) with planned endotracheal intubation will be approached regarding participation in the trial. Design of the study is complex because there is no way to randomize patients to statins or no statins and also no way to take them off the statins prior surgery. So statin use will not be randomized; confounding factors will be accounted for by stratification (every 10 years of age from 40-80 and gender) and statistical adjustment. The investigators propose to test the hypothesis that succinylcholine administration increases plasma myoglobin concentration more in patients who are on statins compared to patients who do not.

Clinical Details

Official title: Effect of Succinylcholine on Patients Using Statins

Study design: Observational Model: Case Control, Time Perspective: Cross-Sectional

Primary outcome: plasma myoglobin concentration

Secondary outcome:

muscle pain

serum potassium concentration

plasma CK concentration

urine myoglobin and onset plus duration of succinylcholine block


Minimum age: 40 Years. Maximum age: 80 Years. Gender(s): Both.


Inclusion Criteria:

- Scheduled for elective surgery not involving orthopedic procedure, muscle and spinal


- ASA Physical Status 1-3

Exclusion Criteria:

- History of liver failure

- History of renal failure

- History of neuromuscular disease

- Increased intraocular pressure

- Recent major burn

- Multiple trauma

- Susceptibility to or family history of malignant hyperthermia

Locations and Contacts

Cleveland Clinic Foundation, Cleveland, Ohio 44195, United States
Additional Information

Starting date: September 2009
Last updated: September 3, 2010

Page last updated: August 23, 2015

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