Effect of Succinylcholine on Patients Using Statins
Information source: Outcomes Research Consortium
Information obtained from ClinicalTrials.gov on October 19, 2009
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Pain
Intervention: Succinylcholine (Drug)
Phase: N/A
Status: Recruiting
Sponsored by: Outcomes Research Consortium Official(s) and/or principal investigator(s):
Daniel I Sessler, MD, Study Chair, Affiliation: Cleveland Clinic
Overall contact:
Gretchen Upton, BA, Phone: 216-444-3289, Email: uptong@ccf.org
Summary
Based on available mechanistic and clinical information, the investigators propose a
nonrandomized study to evaluate the effect of succinylcholine in patients taking statins.
The investigators' purpose is to evaluate the effect of succinylcholine on patients taking
statins. Patients scheduled to undergo elective surgery (other then orthopedic, spinal,
vascular or muscle) with planned endotracheal intubation will be approached regarding
participation in the trial. Design of the study is complex because there is no way to
randomize patients to statins or no statins and also no way to take them off the statins
prior surgery. So statin use will not be randomized; confounding factors will be accounted
for by stratification (every 10 years of age from 40-80 and gender) and statistical
adjustment. The investigators propose to test the hypothesis that succinylcholine
administration increases plasma myglobulin concentration more in patients who are on statins
compared to patients who do not.
Clinical Details
Official title: Effect of Succinylcholine on Patients Using Statins
Study design: Case Control, Cross-Sectional
Primary outcome: plasma myglobulin concentration
Secondary outcome: muscle painserum potassium concentration plasma CK concentration urine myoglobin and onset plus duration of succinylcholine block
Eligibility
Minimum age: 40 Years.
Maximum age: 80 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Scheduled for elective surgery not involving orthopedic procedure, muscle and spinal
surgery
- ASA Physical Status 1-3
Exclusion Criteria:
- History of liver failure
- History of renal failure
- History of neuromuscular disease
- Increased intraocular pressure
- Recent major burn
- Multiple trauma
- Susceptibility to or family history of malignant hyperthermia
Locations and Contacts
Gretchen Upton, BA, Phone: 216-444-3289, Email: uptong@ccf.org
Cleveland Clinic Foundation, Cleveland, Ohio 44195, United States; Recruiting
Alparslan Turan, MD, Principal Investigator
Additional Information
Starting date: September 2009
Ending date: September 2010
Last updated: September 29, 2009
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