Comparison Between Nurse-Administered Propofol Sedation and Diazemuls / Pethidine in Outpatient Colonoscopy

Condition(s) targeted: Colonoscopy

Intervention: diazemuls, pethidine (Drug); Propofol and Alfentanil (Drug)

Phase: N/A

Status: Completed

Sponsored by: North District Hospital

Official(s) and/or principal investigator(s):
Chi-Ming Poon, MBBS, Principal Investigator, Affiliation: North District Hospital

Colonoscopy is a common endoscopic procedure as an investigation of colorectal pathology. Different modalities of pain control have been described in the past. Propofol is a perfect drug for endoscopic procedure since it has the characteristic of fast onset, short half-life and early recovery. Its unfamiliarity and its potential cardiovascular and respiratory side effect make it unpopular to endoscopists. Recent reports showed propofol is safe in bolus titration by nurse in Caucasian in all endoscopic procedures. Our previous pilot study showed nurse administered propofol sedation (NAPS) is effective and safe and highly acceptable by Chinese patients. Here we conduct a randomized controlled study to compare the effectiveness of NAPS versus traditional sedation.

Official title: Nurse-Administered Propofol Sedation by PCA Pump Versus Diazemuls / Pethidine in Outpatient Colonoscopy: A Randomized Controlled Study

Study design: Treatment, Randomized, Single Blind (Outcomes Assessor), Active Control, Single Group Assignment, Efficacy Study

Primary outcome: Pain

Secondary outcome: sedation

Minimum age: 18 Years. Maximum age: 65 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Age 18-65 undergoing elective outpatient colonoscopy

Exclusion Criteria:

- American Society of Anesthesiologist Class III or above

- History of difficult endotracheal intubation

- Known allergy to propofol, eggs or soy products, opioid, benzodiazepines

- previous colectomy

Starting date: July 2005
Ending date: June 2006
Last updated: November 30, 2007