Opioid Rotation From Morphine to Methadone in Treatment of Non-Malignant Pain
Information source: Norwegian University of Science and Technology
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Non-Malignant Chronic Pain
Intervention: Methadone (Drug)
Phase: Phase 3
Status: Completed
Sponsored by: Norwegian University of Science and Technology Official(s) and/or principal investigator(s):
Petter C. Borchgrevink, PhD MD, Principal Investigator, Affiliation: Norwegian University of Science and Technology
Petter C Brochgrevink, MD PhD, Study Chair, Affiliation: Norwegian University of Science and Technology
Summary
Patients with non-malignant pain are switched from morphine to methadone with a nine-months'
follow-up.
Clinical Details
Official title: Opioid Switching From Oral Slow Release Morphine to Oral Methadone May Improve Pain Control in Chronic Non-Malignant Pain: a Nine-Month Follow-Up Study.
Study design: Treatment, Non-Randomized, Open Label, Active Control, Single Group Assignment, Safety/Efficacy Study
Primary outcome: -
Detailed description:
Twelve patients with poor pain control or unacceptable side effects during treatment with
morphine were switched to methadone and followed for nine months in this open prospective
study. Primary outcomes were patient preference for opioid and pain control while physical,
cognitive and role functioning were secondary outcomes. The morphine dose was decreased by
1/3 daily and was replaced with an equianalgesic dose of methadone over a three-day period.
During switching and a one-week dose titration period, patients were given additional
methadone if required. During dose titration one patient experienced sedation requiring
naloxone. Four patients were switched back to morphine due to poor pain control, drowsiness
or sweating. Seven patients preferred long-term (>nine months) treatment with methadone and
reported reduced pain and improved functioning while cognition was not improved. This study
brings novel information on the long-term consequences for pain control, health-related
quality of life and cognitive functioning with a switch from morphine to methadone in the
treatment of chronic non-malignant pain.
Eligibility
Minimum age: 18 Years.
Maximum age: 70 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- 18-70 years of age
- non-malignant chronic pain
- morphine use
Exclusion Criteria:
- addiction
- kidney disorders
Locations and Contacts
Additional Information
Starting date: January 2004
Ending date: January 2005
Last updated: July 24, 2006
|
