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Metabolic Capacity of Israeli Populations

Information source: Hadassah Medical Organization
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Healthy Volunteers

Intervention: Debrisoquine (Drug); Mephenytoin (Drug); Dapsone (Drug); Caffeine (Drug)

Phase: N/A

Status: Terminated

Sponsored by: Hadassah Medical Organization

Official(s) and/or principal investigator(s):
Yoseph Caraco, MD, Principal Investigator, Affiliation: Hadassah Medical Organization


The ability to metabolize drugs varies greatly among individuals. Major fraction of this variability lies in genetic polymorphisms of genes encoding for enzymes responsible for both phase I and phase II reactions. The purpose of this study ws to evaluate the phenotypic activity and the frequency of genetic polymorphisms in different phase II and phase I enzymes among various populations residing in Israel.

Clinical Details

Official title: Phenotypic and Genotypic Evaluation of Cytochrome P450 Isoforms in Populations of Different Ethnic Composition

Study design: Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label

Primary outcome:

Phenotypic measurements of various P450 and non-P450 enzymes involved in drug metabolism.

Frequency of genetic polymorphisms in these enzymes among different Israeli populations.


Minimum age: 20 Years. Maximum age: 50 Years. Gender(s): Both.


Inclusion Criteria:

- Age range 20-50

- Absence of significant disease state

Exclusion Criteria:

- The presence of significant disease states

- The regular use of drugs (including birth control pills)

Locations and Contacts

Hadassah Medical Organization, Jerusalem, Israel
Additional Information

Starting date: July 1995
Last updated: October 28, 2008

Page last updated: August 23, 2015

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