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Metabolic Capacity of Israeli Populations

Information source: Hadassah Medical Organization
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Healthy Volunteers

Intervention: Debrisoquine (Drug); Mephenytoin (Drug); Dapsone (Drug); Caffeine (Drug)

Phase: N/A

Status: Terminated

Sponsored by: Hadassah Medical Organization

Official(s) and/or principal investigator(s):
Yoseph Caraco, MD, Principal Investigator, Affiliation: Hadassah Medical Organization

Summary

The ability to metabolize drugs varies greatly among individuals. Major fraction of this variability lies in genetic polymorphisms of genes encoding for enzymes responsible for both phase I and phase II reactions. The purpose of this study ws to evaluate the phenotypic activity and the frequency of genetic polymorphisms in different phase II and phase I enzymes among various populations residing in Israel.

Clinical Details

Official title: Phenotypic and Genotypic Evaluation of Cytochrome P450 Isoforms in Populations of Different Ethnic Composition

Study design: Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label

Primary outcome:

Phenotypic measurements of various P450 and non-P450 enzymes involved in drug metabolism.

Frequency of genetic polymorphisms in these enzymes among different Israeli populations.

Eligibility

Minimum age: 20 Years. Maximum age: 50 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Age range 20-50

- Absence of significant disease state

Exclusion Criteria:

- The presence of significant disease states

- The regular use of drugs (including birth control pills)

Locations and Contacts

Hadassah Medical Organization, Jerusalem, Israel
Additional Information

Starting date: July 1995
Last updated: October 28, 2008

Page last updated: August 23, 2015

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