Biodiesel Exhaust, Acute Vascular and Endothelial Responses
Information source: University of Edinburgh
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Healthy
Intervention: Forearm venous occlusion plethysmography study (Other)
Phase: N/A
Status: Completed
Sponsored by: University of Edinburgh Official(s) and/or principal investigator(s): Jenny A Bosson Damewood, MD PhD, Principal Investigator, Affiliation: Umeå University
Summary
Exposure to particulate air pollution has been shown to increase cardiovascular mortality
and morbidity, and in previous controlled exposure studies has been shown to have acute
cardiovascular and respiratory effects. The last decade has seen an unprecedented drive
towards finding a bioeconomical and renewable source of fuel in order to reduce our
dependence on fossil fuels. Although both biodiesel and bioethanol have emerged as
contenders for future fuels, biodiesel remains as the strongest contender within European
markets. In 2007 researchers at the EPA released a commentary, which concluded that the
assumed correlation between the chemical composition of biodiesel exhaust and a reduction in
health effects was only hypothetical. They suggested that there was a clear need for the
study of health effects in humans regarding biofuel exhaust. In this project the
investigators aim to investigate the cardiovascular, respiratory and inflammatory responses
to biofuel exhaust exposure in healthy volunteers.
Clinical Details
Official title: Inhalation of Dilute Biodiesel Exhaust: Acute Vascular and Endothelial Responses
Study design: Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Basic Science
Primary outcome: Vascular vasomotor and fibrinolytic function
Secondary outcome: Respiratory function testsInflammatory markers Central arterial stiffness
Eligibility
Minimum age: 20 Years.
Maximum age: 55 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- 20 healthy, non-smoking subjects, age 20-55 year old, both genders.
All subjects undergo a general health examination and are required to have:
Normal clinical examination Normal EKG Normal routine blood tests Normal lung function
Exclusion Criteria:
- Cardiovascular disease
- Diabetes Mellitus
- Asthma and/or allergy
- Respiratory infection within 3 weeks of the study
- Antioxidant- and/or vitamin supplementation within 2 weeks prior to, as well as
during the course of the study. (incl vitamin C, Acetylcysteine)
- Female subjects will take a urinary pregnancy test before each exposure and will be
excluded if this is positive.
Locations and Contacts
Umeå University Hospital, Umeå 901 85, Sweden
Additional Information
Starting date: April 2011
Last updated: November 30, 2011
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