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The Effect of Intravenous Lidocaine on Pain After Lumbar Spinal Fusion

Information source: Chung-Ang University Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Postoperative Pain

Intervention: Intravenous lidocaine injection (Drug); Intravenous normal saline injection (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: Chung-Ang University Hospital

Official(s) and/or principal investigator(s):
Hyun Kang, Ph.D.,, Study Chair, Affiliation: Chung-Ang University Hospital
Young-Baeg Kim, Ph.D., Study Director, Affiliation: Chung-Ang University Hospital


This prospective randomized study aims to evaluate the effectiveness of intravenous lidocaine injection on the relief of pain in patients undergoing 1-level posterior lumbar fusion. A total of 54 patients will be randomized into one of two groups (group C or group I) based on Excel number generation. Patients in group C will receive received normal saline intravenous injection, and patients in group I will receive an intravenous bolus injection of 1. 5 mg/kg lidocaine followed by a continuous lidocaine infusion of 2 mg/kg/hr. Visual analogue scale pain scores, fentanyl consumption and the frequency at which patients pushed the button (FPB) of a patient-controlled analgesia system will be recorded at 4, 12, 24, 48 hours postoperatively.

Clinical Details

Official title: Intravenous Lidocaine for Effective Pain Relief After Posterior Lumbar Spinal Fusion: a Prospective, Randomized, Double-blind, Placebo-controlled Study

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: Postopeartive pain measured using Visual analogue scale at postoperative 4hour

Secondary outcome:

visual analogue scale 12 hour

visual analogue scale 24hour

Visual analogue scale 48hour

Opioid consumption 4hour

Opioid consumption 24hour

Opioid consumption 12 hour

Opioid consumption 48hour

FPB 4 hour

FPB 12 hour

FPB 24 hour

FPB 48 hour


Minimum age: 18 Years. Maximum age: 85 Years. Gender(s): Both.


Inclusion Criteria:

- 1-level posterior lumbar fusion

Exclusion Criteria:

- mental change

- allergy to local anesthetics

- chronic analgesics user

Locations and Contacts

ChungAng University, Seoul, Korea, Republic of
Additional Information

Starting date: March 2011
Last updated: August 1, 2013

Page last updated: August 23, 2015

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