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Progesterone Support of FET

Information source: Mayo Clinic
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Frozen Embryo Pregnancy Rate

Intervention: Progesterone Vaginal Suppositories (Drug); Intramuscular Progesterone-in-Oil (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: Charles Coddington

Official(s) and/or principal investigator(s):
Charles Coddington, MD, Principal Investigator, Affiliation: Mayo Clinic

Summary

There have been two very common forms of progesterone administration that have been used during ovulation induction, in vitro fertilization (IVF) and embryo transfers. There are currently no randomized clinical trials to demonstrate which method of progesterone administration is more effective for frozen embryo transfer. We raise the question: Is there a difference between the two accepted methods of progesterone administration, intramuscular and vaginal suppositories, for frozen embryo transfer? Studies for fresh embryo transfer after in vitro fertilization, have demonstrated that there is not a difference between the two methods of progesterone administration. We will evaluate the question for frozen embryo transfer.

Clinical Details

Official title: Progesterone Support for Frozen Embryo Transfer: Intramuscular Versus Vaginal Suppository - A Prospective, Randomized, Controlled Trial

Study design: Observational Model: Cohort, Time Perspective: Prospective

Primary outcome: Clinical Pregnancy Rate

Secondary outcome: Implantation rate

Eligibility

Minimum age: 20 Years. Maximum age: 50 Years. Gender(s): Female.

Criteria:

Inclusion Criteria:

- Females < 50 years of age

- Having frozen embryo transfer at Mayo Clinic

- Embryos have been created prior to age 42

- Willing to be randomized to either method of progesterone administration

Exclusion Criteria:

- Diagnosis of severe medical illness

- Uterine lesions affecting the cavity or endometrium

- Uterine anomaly

- Presence of hydrosalpinx

- Extreme difficulty with embryo transfer

Locations and Contacts

Mayo Clinic in Rochester, Rochester, Minnesota 55905, United States
Additional Information

Starting date: February 2010
Last updated: May 8, 2013

Page last updated: August 23, 2015

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