Evaluation of Metabolic Activity of Liver Metastases by FDG-PET Scanning
Information source: Radboud University
Information obtained from ClinicalTrials.gov on February 07, 2013
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Colorectal Neoplasms
Intervention: FDG-PET (Procedure)
Phase: N/A
Status: Recruiting
Sponsored by: Radboud University Official(s) and/or principal investigator(s):
Theo Ruers, PhD, Principal Investigator, Affiliation: Radboud University
Overall contact:
Charlotte Peeters, MD, Phone: +31-24-3611111, Ext: 17365, Email: C.Peeters@chir.umcn.nl
Summary
The purpose of this study is to evaluate the effect of primary tumor resection on the
metabolic activity of metastases in patients with a colorectal primary tumor and synchronous
liver metastases by positron emission tomography (PET) with 2-deoxy-2-fluoro[18F]-D-glucose
(FDG-PET) scanning.
Clinical Details
Official title: Exploratory Study on FDG-PET Scanning in Evaluating the Metabolic Activity of Liver Metastases Before and After Resection of the Primary Tumor in Patients With a Colorectal Malignancy
Study design: Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Primary outcome: Increase in metabolic activity of liver metastases after resection of the primary tumor compared to the activity of metastases in patients without primary tumor resection
Detailed description:
The goal of this study is to evaluate the activity of liver metastases before and after
resection of the primary tumor. Non-invasive assessment of tumor metabolism is possible in
vivo by means of positron emission tomography (PET)-scanning. Therefore, FDG-PET scan offers
a suitable approach to determine the influence of removal of a primary colorectal tumor on
metabolic activity of the liver metastases. The FDG uptake in the liver metastases is
quantified by calculating standardised uptake values (SUVs).
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Colorectal cancer and synchronous liver metastases
Exclusion Criteria:
- Pregnancy
Locations and Contacts
Charlotte Peeters, MD, Phone: +31-24-3611111, Ext: 17365, Email: C.Peeters@chir.umcn.nl
Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland 6500 HB, Netherlands; Recruiting
Charlotte Peeters, MD, Phone: +31-24-3611111, Ext: 17365, Email: C.Peeters@chir.umcn.nl
Theo Ruers, PhD, Phone: +31-24-3611111, Ext: 17365, Email: T.Ruers@chir.umcn.nl
Additional Information
Starting date: September 2003
Last updated: September 20, 2007
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