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Study of Quetiapine Treatment for Cannabis Dependence

Information source: New York State Psychiatric Institute
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Cannabis Dependence

Intervention: quetiapine (Drug)

Phase: Phase 2

Status: Completed

Sponsored by: New York State Psychiatric Institute

Official(s) and/or principal investigator(s):
John J Mariani, MD, Principal Investigator, Affiliation: Columbia University

Summary

Marijuana is the most commonly used illicit drug in the United States. However, the treatment options for cannabis dependence are limited; notably, no effective pharmacotherapy has been developed. Conceptually, the ideal medication treatment for cannabis dependence would: 1. be safe when administered to patients actively using cannabis 2. reduce cannabis intake and promote abstinence 3. treat the symptoms of cannabis withdrawal 4. reduce craving and relapse risk 5. have a low abuse liability.

Clinical Details

Official title: Open-Label Pilot Study of Quetiapine Treatment for Cannabis Dependence

Study design: Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Maximum tolerated dose of quetiapine

Detailed description: Conceptually, the pharmacodynamic and clinical actions of quetiapine suggest that it may be useful for cannabis dependence. By antagonizing dopamine, quetiapine may interfere with the reinforcing effects of cannabis, while serotonin type 2A, histamine type 1, and adrenergic receptor antagonism may reduce cannabis withdrawal symptoms, primarily by sedating and anxiolytic effects. The proposed research project is an open-label pilot study to evaluate the tolerability and ideal target dosing range for quetiapine treatment of cannabis dependence over an eight-week period. The purpose of this pilot study is to obtain preliminary data regarding the potential efficacy, tolerability and safety of quetiapine treatment of cannabis dependence before conducting a larger double-blind trial.

Eligibility

Minimum age: 18 Years. Maximum age: 65 Years. Gender(s): Both.

Criteria:

Inclusion Criteria: 1. Between the ages of 18-65 2. Meets DSM-IV criteria for current cannabis dependence 3. Seeking treatment for cannabis dependence 4. Reports using cannabis an average of five days per week over the past 28 days 5. Capable of giving informed consent and complying with study procedures Exclusion Criteria: 1. Lifetime history of DSM-IV diagnosis of schizophrenia, schizoaffective disorder, or bipolar disorder 2. Current DSM-IV criteria for any other psychiatric disorder that may, according to the investigator's judgment, require either pharmacological or non-pharmacological intervention over the course of the study 3. Receiving prescribed psychotropic medication 4. Known history of allergy, intolerance, or hypersensitivity to quetiapine 5. Pregnancy, lactation, or failure to use adequate contraceptive methods in female patients who are currently engaging in sexual activity with men 6. Unstable medical conditions, such as poorly controlled diabetes or hypertension, which might make participation hazardous 7. Current DSM-IV diagnosis of substance dependence other than cannabis or nicotine dependence 8. Are legally mandated to participate in a substance use disorder treatment program 9. Increased risk for suicide 10. Diabetes (whether controlled or not), hyperglycemia (fasting glucose > 100 mg/dl), obesity (BMI > 30) and elevated lipids (cholesterol > 200 mg/dl; triglycerides > 150 mg/dl).

Locations and Contacts

Substance Treatment Research Service (STARS) of Columbia University, New York, New York 10032, United States
Additional Information

Starting date: August 2009
Last updated: January 15, 2014

Page last updated: August 23, 2015

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