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Dexamethasone With TAP Block Increasing the Duration of the Peripheral Nerve Block in Caesarian Section

Information source: Cairo University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Pain

Intervention: Dexamethasone in addition to TAP block in dose of 4 mg (Drug); Dexamethasone in combination with TAP block in dose of 8 mg (Drug); Dexamethasone intravenous 4mg+ TAP block (Drug); Dexamethasone intravenous in addition to TAP block in dose of 8 mg (Drug); control (Other)

Phase: N/A

Status: Not yet recruiting

Sponsored by: Cairo University

Official(s) and/or principal investigator(s):
Hassan Ali, LECTURER, Principal Investigator, Affiliation: Anesthesia department, faculty of medicine ,Cairo university

Overall contact:
Hassan Ali, Phone: +201001733687, Email: hassan364@hotmail.com

Summary

Nowadays Cesarean sections became the most popular surgery worldwide with the consumption of the hospital resources and the continuous need to decrease the costs, work load and medical stuff engagement. One of the most common problem is the need to control pain post operatively, this issue increase the work load over the pain management team and increase lead to patient in satisfaction. This study will test the usage of dexamethasone with different doses (4 and 8 mg) either locally or intravenously (I. V.) with the local anesthetics in TAP (transversus abdominis plane) block to prolong the duration of the block and decrease the need of post-operative analgesics.

Clinical Details

Official title: Dexamethasone With TAP Block Increasing the Duration of the Peripheral Nerve Block in Caesarian Section

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: level of pain according to verbal analogue scale

Detailed description: Nowadays Cesarean sections became the most popular surgery worldwide with the consumption of the hospital resources and the continuous need to decrease the costs, work load and medical stuff engagement. One of the most common problem is the need to control pain post operatively, this issue increase the work load over the pain management team and increase lead to patient in satisfaction.(1,2,3) The presence of the adjuvant which can be added to the conventional anesthetic medications can prolong the duration of action and decrease the need for frequent post-operative analgesics.(4,5) The idea of adding a catheter or placing an epidural catheter still have a quite limitation regarding the patients compliance, delayed ambulation and high costs, these limitations redirect the anesthetist again to the use of adjuvant with a single shot block to prolong the duration of it and decrease the need of subsequent analgesics.(6) Dexamethasone proved to be an effective adjuvant in prolongation of the nerve blocks with the question regarding the proper route and dose (7,8,9,10). This study will test the usage of dexamethasone with different doses (4 and 8 mg) either locally or intravenously (I. V.) with the local anesthetics in TAP (transversus abdominis plane) block to prolong the duration of the block and decrease the need of post-operative analgesics.

Eligibility

Minimum age: 18 Years. Maximum age: 45 Years. Gender(s): Female.

Criteria:

Inclusion Criteria:

- Any patient ASA (american society of anesthesia) I or II,

- aged between 18 and 45 scheduled for elective cesarean section.

Exclusion Criteria:

- patient refusal,

- age below 18 or above 45 years,

- coagulopathy with INR (international normalized ratio) more than 1. 5 or platelets

below 100000,

- uncontrolled diabetes, uncontrolled hypertensive, addict patient,

- psychological instability, and

- allergy to the used drugs,

- failure of spinal,

- conversion to general of anesthesia,

- failure of application of TAP block.

Locations and Contacts

Hassan Ali, Phone: +201001733687, Email: hassan364@hotmail.com

Cairo University, Cairo, Giza 1234, Egypt
Additional Information

Starting date: May 2015
Last updated: May 7, 2015

Page last updated: August 23, 2015

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