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Efficacy of Serotonin-Norepinephrine Reuptake Inhibitor (SNRI) Treatment on Prefrontality in Patients With Generalized Anxiety Disorder (GAD) and Other Comorbidities

Information source: START Clinic for Mood and Anxiety Disorders
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Generalized Anxiety Disorder

Intervention: Desvenlafaxine (Drug)

Phase: Phase 4

Status: Recruiting

Sponsored by: START Clinic for Mood and Anxiety Disorders

Overall contact:
Martin A Katzman, BSc, MD, FRCPC, Phone: 416-598-9344, Email: mkatzman@startclinic.ca


This is an open-label flexible-dose pilot study evaluating the efficacy, safety, and tolerability of Pristiq (desvenlafaxine) in outpatient subjects diagnosed with Generalized Anxiety Disorder (GAD) with or without comorbidities that are secondary to the GAD. Primary trial objective is to evaluate the efficacy of Pristiq (desvenlafaxine) SNRI treatment 50 to 100 mg once daily in the treatment of GAD with or without comorbidities. Secondary trial objective is to determine whether or not treatment outcome in GAD is related to changes in cortical prefrontal activity of norepinephrine.

Clinical Details

Study design: Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Mean changes in the Hamilton Anxiety Rating Scale from baseline visit to week 16.

Secondary outcome: Mean change from baseline to week 16 on the measures of prefrontality including: Frontal System Behavioural Scale and Behaviour Rating Inventory of Executive Function-Adult


Minimum age: 18 Years. Maximum age: 65 Years. Gender(s): Both.


Inclusion Criteria:

- The patient has provided signed informed consent.

- Outpatients aged 18-65 (extremes included).

- Patients with a primary diagnosis of GAD according to DSM IV (300. 23) criteria

(diagnosis to be made using the Mini International Neuropsychiatric Interview; MINI Version 6. 0.0). Patients with co-morbid anxiety disorders will be permitted, as long as GAD is judged to be the primary diagnosis.

- Patients who score a HAM-A of ≥ 20 at both Screening and Baseline, and ≥ 10 on the

psychic and somatic anxiety factors.

- On the basis of physical examination, medical history, and basic laboratory

screening, patient is, in the investigator's opinion, in a suitable condition.

- Willing and able to attend study appointments in the correct time windows.

Exclusion Criteria:

- Any other axis I diagnosis that was a primary disorder in the previous six months.

- Alcohol or drug abuse as defined in the DSM IV (300. 23) within the last six months.

- Mania, hypomania as defined in the DSM IV (300. 23).

- Any psychotic disorder.

- Eating disorders as defined in the DSM IV (300. 23).

- Any cognitive disorder or dementia within 3 months before the baseline visit.

- Clinical interpretation of apparent suicide risk.

- Continuation or commencement of formal psychotherapy.

- Current use of or commencement of antidepressant and anxiolytic medications.

- Failure on no more than 2 antidepressants (either SSRIs or SNRIs to exclude any

treatment resistance.

- Patients, who have been on an antidepressant or other anxiolytic prior to the study,

will have discontinued it more than two weeks prior to entry into the study. Those who have been on fluoxetine, will have been off of it for at least 5 weeks.

- Patients who have been on a herbal or alternative treatment judged to be potentially

anxiolytic or with psychobiological activity (e. g. St. John's Wort, S-adenosylmethionine), will have terminated usage of the agent more than two weeks prior to entering the study.

- Scores on the Hamilton Depression Rating Scale (HAM-D) > 15, at screening visit 1

- Laboratory values at screening or in medical history that may be considered through

clinical interpretation to be significant.

- Diseases that could through clinical interpretation interfere with the assessments of

safety, tolerability and efficacy.

- Serious illness: Liver or renal insufficiency, cardiac, vascular, pulmonary,

gastrointestinal, endocrine, neurological, infectious, neoplastic or metabolic disturbance.

- If female, the subject is pregnant or lactating or intending to become pregnant

before, during or within 30 days after participating in this study; or intending to donate ova during such time period.

- The subject has received electroconvulsive therapy, vagal nerve stimulation, or

repetitive transcranial magnetic stimulation within 6 months prior to Screening.

- The patient is, in the opinion of the investigator, unlikely to comply with the

clinical trial protocol or is unsuitable for any reason.

- Known allergy or intolerance to desvenlafaxine or its excipients.

Locations and Contacts

Martin A Katzman, BSc, MD, FRCPC, Phone: 416-598-9344, Email: mkatzman@startclinic.ca

START Clinic for Mood and Anxiety Disorders, Toronto, Ontario M4W 2N4, Canada; Recruiting
Martin A Katzman, BSc, MD, FRCPC, Phone: 416-598-9344, Email: mkatzman@startclinic.ca
Martin A Katzman, BSc, Principal Investigator
Additional Information

Starting date: January 2013
Last updated: May 27, 2015

Page last updated: August 23, 2015

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