This is a phase III B, prospective, interventional, open-label, single-arm, multicenter
study to provide regorafenib to subjects diagnosed with metastatic colorectal cancer who
have failed after standard therapy and for whom no therapy alternatives exist, in the time
between positive results and approval / availability on the market, and to collect safety
data for regorafenib until market access.
Regorafenib is an oral (i. e. taken by mouth) multi-targeted kinase inhibitor. A kinase
inhibitor targets certain key proteins that are essential for the survival of the cancer
cell. By specifically targeting these proteins, regorafenib may stop cancer growth. The
growth of the tumor may be decreased by preventing these specific proteins from functioning.
The primary endpoint of this study will be safety.
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Bayer Clinical Trials Contact, Email: clinical-trials-contact@bayerhealthcare.com
Wien 1090, Austria
Bruxelles - Brussel 1000, Belgium
Bruxelles - Brussel 1070, Belgium
Bruxelles - Brussel 1200, Belgium
Edegem 2650, Belgium
Leuven 3000, Belgium
Roeselare 8800, Belgium
Quebec G1R 2J6, Canada
Brno 65 653, Czech Republic
Praha 18081, Czech Republic
Aarhus C 8000, Denmark
Copenhagen 2100, Denmark
Helsinki 00180, Finland
HUS 00029, Finland
Avignon 84000, France
Bordeaux, France
CLERMONT-FERRAND Cedex 1 63003, France
Le Mans Cedex 2 72015, France
Lille Cedex 59020, France
Lille Cedex 59037, France
Marseille 13005, France
Montpellier Cedex 34298, France
Nice 06102, France
Paris Cedex 15 75908, France
Paris 75571, France
Paris 75651, France
Reims Cedex 51092, France
Saint Herblain 44805, France
Strasbourg Cedex 67085, France
Toulouse 31059, France
Berlin 12200, Germany
Hamburg 20251, Germany
Heraklion 711 10, Greece
Kifissia / Athens 14564, Greece
Budapest 1097, Hungary
Cork, Ireland
Dublin 24, Ireland
Beer Sheva 8410101, Israel
Haifa 3109601, Israel
Jerusalem 9112001, Israel
Petah Tikva 4941492, Israel
Tel Aviv 6423906, Israel
Ancona 60126, Italy
Brescia 25124, Italy
Firenze 50134, Italy
Genova 16132, Italy
Milano 20133, Italy
Milano 20162, Italy
Modena 41124, Italy
Napoli 80131, Italy
Padova 35128, Italy
Palermo 90127, Italy
Pisa 56126, Italy
Reggio Emilia 42100, Italy
Roma 00168, Italy
Aguascalientes 20230, Mexico
México, D.F. 14080, Mexico
Oaxaca 68000, Mexico
Veracruz 91910, Mexico
Amsterdam 1081 HV, Netherlands
Amsterdam 1105 AZ, Netherlands
Leiden 2333 ZA, Netherlands
Oslo 0450, Norway
Bialystok 15-027, Poland
Poznan 60-569, Poland
Coimbra 3030-075, Portugal
Porto 4200- 319, Portugal
Kazan 420029, Russian Federation
Krasnodar 350040, Russian Federation
Moscow 115478, Russian Federation
Moscow 119991, Russian Federation
Obninsk 249036, Russian Federation
Orenburg 460021, Russian Federation
St. Petersburg 197022, Russian Federation
St. Petersburg 197758, Russian Federation
A Coruña 15006, Spain
Barcelona 08035, Spain
Barcelona 08036, Spain
Madrid 28007, Spain
Madrid 28034, Spain
Madrid 28040, Spain
Madrid 28046, Spain
Madrid 28041, Spain
Málaga 29010, Spain
Sevilla 41013, Spain
Valencia 46014, Spain
Linköping 581 85, Sweden
Uppsala 751 85, Sweden
Bern 3010, Switzerland
Genève 1211, Switzerland
Zürich 8091, Switzerland
Manchester M20 4BX, United Kingdom
Calgary, Alberta T2N 4N2, Canada
Edmonton, Alberta T6G 1Z2, Canada
Córdoba, Andalucía 14004, Spain
Esslingen, Baden-Württemberg 73730, Germany
Freiburg, Baden-Württemberg 79106, Germany
Heidelberg, Baden-Württemberg 69120, Germany
Mannheim, Baden-Württemberg 68167, Germany
Stuttgart, Baden-Württemberg 70199, Germany
Ulm, Baden-Württemberg 89081, Germany
Badalona (Barcelona), Barcelona 08916, Spain
Hospitalet de Llobregat, Barcelona 08907, Spain
Sabadell, Barcelona 08208, Spain
Basel, Basel-Stadt 4031, Switzerland
München, Bayern 81377, Germany
München, Bayern 81737, Germany
München, Bayern 81925, Germany
Duarte, California 91010, United States
La Jolla, California 92093-0987, United States
La Jolla, California 92037, United States
Long Beach, California 90813, United States
Los Angeles, California 90033, United States
Orange, California 92868-3201, United States
Santa Maria, California 93454, United States
Santander, Cantabria 39008, Spain
Denver, Colorado 80218, United States
New Haven, Connecticut 06520, United States
Washington, District of Columbia 20007, United States
Mexico, D.F., Distrito Federal 01120, Mexico
Mexico, D.F., Distrito Federal 14050, Mexico
México, Distrito Federal 14080, Mexico
Aventura, Florida 33180, United States
Jacksonville, Florida 32224, United States
Miami Beach, Florida 33140, United States
Ocala, Florida 34474, United States
Orlando, Florida 32804, United States
San Giovanni Rotondo, Foggia 71013, Italy
Atlanta, Georgia 30318, United States
Columbus, Georgia 31904, United States
Savannah, Georgia 31405, United States
Chur, Graubünden 7000, Switzerland
Irapuato, Guanajuato 36500, Mexico
Park Ridge, Illinois 60068, United States
Cedar Rapids, Iowa 52403, United States
Sioux City, Iowa 51101, United States
Guadalajara, Jalisco 44670, Mexico
Louisville, Kentucky 40202, United States
Leicester, Leicestershire LE1 5WW, United Kingdom
New Orleans, Louisiana 70121, United States
Shreveport, Louisiana 71130, United States
Brewer, Maine 04412, United States
Boston, Massachusetts 02215-5450, United States
Burlington, Massachusetts 01805, United States
Ann Arbor, Michigan 48106, United States
Detroit, Michigan 48202, United States
Detroit, Michigan 48201, United States
Rozzano, Milano 20089, Italy
Rochester, Minnesota 55905, United States
Jackson, Mississippi 39202, United States
Jefferson City, Missouri 65109, United States
Toluca, México 50180, Mexico
Omaha, Nebraska 68106, United States
Las Vegas, Nevada 89169, United States
Lebanon, New Hampshire 03756, United States
Concord, New South Wales 2139, Australia
St Leonards, New South Wales 2065, Australia
Bronx, New York 10461, United States
Lake Success, New York 11042, United States
New York, New York 10021, United States
New York, New York 10016, United States
New York, New York 10003, United States
Stony Brook, New York 11794, United States
Hannover, Niedersachsen 30625, Germany
Oldenburg, Niedersachsen 26133, Germany
Bochum, Nordrhein-Westfalen 44892, Germany
Essen, Nordrhein-Westfalen 45122, Germany
Herne, Nordrhein-Westfalen 44625, Germany
Köln, Nordrhein-Westfalen 50924, Germany
Leverkusen, Nordrhein-Westfalen 51375, Germany
Mönchengladbach, Nordrhein-Westfalen 41063, Germany
Porta Westfalica, Nordrhein-Westfalen 32457, Germany
Recklinghausen, Nordrhein-Westfalen 45657, Germany
Charlotte, North Carolina 28203, United States
Winston-Salem, North Carolina 27157, United States
Fargo, North Dakota 58122, United States
Wels, Oberösterreich 4600, Austria
Cincinnati, Ohio 45219, United States
Cleveland, Ohio 44195, United States
Toledo, Ohio 43617, United States
Mississauga, Ontario L5M 2N1, Canada
Oshawa, Ontario L1G 2B9, Canada
Toronto, Ontario M4N 3M5, Canada
Portland, Oregon 97239, United States
Philadelpahia, Pennsylvania 19107, United States
Philadelphia, Pennsylvania 19111-2497, United States
Philadelphia, Pennsylvania 19104, United States
Montreal, Quebec H2W 1S6, Canada
Trier, Rheinland-Pfalz 54290, Germany
Providence, Rhode Island 02908, United States
Dresden, Sachsen 01307, Germany
Halle, Sachsen-Anhalt 06120, Germany
Magdeburg, Sachsen-Anhalt 39104, Germany
Woodville South, South Australia 5011, Australia
Charleston, South Carolina 29414, United States
Sumter, South Carolina 29150, United States
Graz, Steiermark 8036, Austria
Memphis, Tennessee 38120, United States
Nashville, Tennessee 37232, United States
Dallas, Texas 75390-9110, United States
Temple, Texas 76508, United States
Innsbruck, Tirol 6020, Austria
Footscray, Victoria 3011, Australia
Parkville, Victoria 3050, Australia
Portsmouth, Virginia 23704, United States
Richmond, Virginia 23298-0037, United States
Seattle, Washington 98104, United States