Preoperative NSAID to Colorectal Cancer Patients
Information source: Göteborg University
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Colorectal Cancer
Intervention: Indomethacin, celecoxib, esomeprazole (Drug)
Phase: Phase 4
Status: Completed
Sponsored by: Göteborg University Official(s) and/or principal investigator(s):
Kent Lundholm, MD, prof, Principal Investigator, Affiliation: Göteborg University
Summary
The study is designed to evaluate effects of NSAIDs on immune activity inside and close to
tumor tissue in patients with colorectal cancer.
Clinical Details
Official title: Preoperative Treatment With NSAID in Colorectal Cancer Patients in Relationship to Tumor Host Reactions
Study design: Treatment, Randomized, Open Label, Active Control, Parallel Assignment, Efficacy Study
Primary outcome: Immune reactivity
Detailed description:
Study and control patients are randomized to receive preoperative treatment with indomethacin
or celecoxib compared to sham treatment. Tumor biopsies are taken at operation and used for
analyses of tumor immunity and gene expression.
Eligibility
Minimum age: 40 Years.
Maximum age: 80 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Colon carcinoma scheduled for curative operation
Exclusion Criteria:
- Diabetes, steroid medication, liver and kidney impairment
Locations and Contacts
Department of Surgery, Göteborg SE 41345, Sweden
Additional Information
Göteborg University
Starting date: December 1998
Ending date: May 2007
Last updated: May 15, 2007
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