Epidemiology and Control of Mansonella Perstans Infection in Uganda
Information source: DBL -Institute for Health Research and Development
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Mansonelliasis; Pruritus; Lymphoedema; Abdominal Pains
Intervention: ivermectin and albendazole (Drug)
Sponsored by: DBL -Institute for Health Research and Development
Official(s) and/or principal investigator(s):
Asanta M Asio, Msc, Principal Investigator, Affiliation: Vector control Division, Kampala, Uganda
Mansonella perstans (M. perstans) infection is widespread in Uganda. Knowledge about the
epidemiology of this infection, and of the morbidity it induces is poor, and no effective
treatment is available. The study aims at providing data on diagnostic, epidemiological,
morbidity and treatment aspects of M. perstans infections in Uganda.
Official title: Studies on the Epidemiology and Control of Mansonella Perstans Infection in Uganda
Study design: Treatment, Randomized, Double-Blind, Placebo Control, Single Group Assignment, Safety/Efficacy Study
microfilariae periodicity patterns
epidemiology of M. perstans at community level
clinical spectre among infected
reduction in microfilaraemia
Secondary outcome: treatment effect on clinical manifestations
Overall objective: to investigate diagnostic, epidemiological and treatment aspects of M.
perstans in Uganda with relevance to control
1. To establish the pattern of diurnal periodicity of M. perstans microfilaraemia in
2. To establish the patterns of M. perstans microfilaraemia and possible clinical
manifestations related to this infection in two communities with medium to high
3. To determine the efficacy of ivermectin alone and the combination of ivermectin and
albendazole on M. perstans microfilaraemia.
Minimum age: 5 Years.
Maximum age: N/A.
- Individuals >= 5 years with or without M. perstans infection
- Individuals < 5 years
- Pregnant women
Locations and Contacts
Luwero, Luwero and Mukono, Luwero and Mukono Districts, Uganda
Starting date: November 2005
Ending date: February 2006
Last updated: April 19, 2007