DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more



Treatment for Calcium Phosphate Kidney Stone Disease

Information source: University of Texas Southwestern Medical Center
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Calcium Phosphate Kidney Stones

Intervention: Placebo (Drug); Citric Acid (Dietary Supplement); Potassium Citrate (Dietary Supplement); Indapamide (Drug)

Phase: Phase 2

Status: Recruiting

Sponsored by: University of Texas Southwestern Medical Center

Official(s) and/or principal investigator(s):
Naim M Maalouf, MD, Principal Investigator, Affiliation: UT Southwestern Medical Center

Overall contact:
Ann Heard-Sakhaee, RN, Phone: 214-648-4893, Email: ann.heard-sakhaee@utsouthwestern.edu

Summary

The investigators will examine in two studies whether citric acid or potassium citrate can reduce calcium phosphate saturation in urine of Calcium Phosphate stone formers.

Clinical Details

Official title: Pharmacological Therapy for Calcium Phosphate Urolithiasis

Study design: Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Primary outcome: Urinary calcium phosphate saturation

Eligibility

Minimum age: 21 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria: Aim 1

- Hypocitraturic CaP stone formers

- urine citrate <320mg/d

- elevated pH as 24-hr urine pH above 6. 40

- >21 years

Aim 2

- Hypercalciuric CaP stone formers

- 24hr urine calcium >250mg/d in women and >300mg/d in men prior to indapamide use

- high pH as >6. 40 in the absence of urinary tract infection

- >21 years

Locations and Contacts

Ann Heard-Sakhaee, RN, Phone: 214-648-4893, Email: ann.heard-sakhaee@utsouthwestern.edu

UT Southwestern Medical Center, Dallas, Texas 75390-8885, United States; Recruiting
Naim M Maalouf, MD
Additional Information

Starting date: July 2012
Last updated: February 3, 2015

Page last updated: August 23, 2015

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017