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Treatment for Calcium Phosphate Kidney Stone Disease

Information source: University of Texas Southwestern Medical Center
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Calcium Phosphate Kidney Stones

Intervention: Placebo (Drug); Citric Acid (Dietary Supplement); Potassium Citrate (Dietary Supplement); Indapamide (Drug)

Phase: Phase 2

Status: Recruiting

Sponsored by: University of Texas Southwestern Medical Center

Official(s) and/or principal investigator(s):
Naim M Maalouf, MD, Principal Investigator, Affiliation: UT Southwestern Medical Center

Overall contact:
Ann Heard-Sakhaee, RN, Phone: 214-648-4893, Email: ann.heard-sakhaee@utsouthwestern.edu


The investigators will examine in two studies whether citric acid or potassium citrate can reduce calcium phosphate saturation in urine of Calcium Phosphate stone formers.

Clinical Details

Official title: Pharmacological Therapy for Calcium Phosphate Urolithiasis

Study design: Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Primary outcome: Urinary calcium phosphate saturation


Minimum age: 21 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria: Aim 1

- Hypocitraturic CaP stone formers

- urine citrate <320mg/d

- elevated pH as 24-hr urine pH above 6. 40

- >21 years

Aim 2

- Hypercalciuric CaP stone formers

- 24hr urine calcium >250mg/d in women and >300mg/d in men prior to indapamide use

- high pH as >6. 40 in the absence of urinary tract infection

- >21 years

Locations and Contacts

Ann Heard-Sakhaee, RN, Phone: 214-648-4893, Email: ann.heard-sakhaee@utsouthwestern.edu

UT Southwestern Medical Center, Dallas, Texas 75390-8885, United States; Recruiting
Naim M Maalouf, MD
Additional Information

Starting date: July 2012
Last updated: February 3, 2015

Page last updated: August 23, 2015

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