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Effect of Zoledronic Acid on Femoral Bone Loss Following Total Hip Arthroplasty

Information source: Spokane Joint Replacement Center
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Osteoporosis

Intervention: Zoledronic acid (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: Spokane Joint Replacement Center

Summary

In a randomized, double-blind trial, BMD of the operated proximal femur after total hip replacement measured by dual-energy x-ray absorptiometry (DXA) were compared for up to two years in patients receiving IV ZOL 5 mg infusion (n = 27) or placebo (IV saline infusion; n = 24) at two weeks and one year after surgery.

Clinical Details

Official title: Effect of Zoledronic Acid on Femoral Bone Loss Following Total Hip Arthroplasty

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: Bone mineral density

Eligibility

Minimum age: N/A. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Patients undergoing primary elective total hip replacement

Exclusion Criteria:

- Osteoporosis (BMD ≤-2. 5)

- Trauma to the operated femur, hip revisions, femoral dysplasia, trochanteric

osteotomy, inflammatory arthritis

- Severe renal impairment

- Use of any medications affecting BMD

- Known sensitivity to bisphosphonates

- Severe dental problems, and pregnancy or being able to conceive and not using

reliable birth control methods

Locations and Contacts

Additional Information

Starting date: January 2005
Last updated: January 21, 2015

Page last updated: August 23, 2015

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