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The Chloroquine for Influenza Prevention Trial

Information source: National University Hospital, Singapore
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Influenza

Intervention: Chloroquine (Drug); Placebo (Drug)

Phase: Phase 2

Status: Active, not recruiting

Sponsored by: National University Hospital, Singapore

Official(s) and/or principal investigator(s):
Nicholas I Paton, MD FRCP, Study Chair, Affiliation: National University, Singapore
Lawrence Lee, MD PhD, Principal Investigator, Affiliation: National University, Singapore


A randomised controlled trial to determine the efficacy of chloroquine for the prevention of influenza

Clinical Details

Official title: A Randomised, Double-blind, Placebo Controlled Trial of Chloroquine for the Prevention of Influenza

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Primary outcome: Laboratory-confirmed influenza-like illness

Secondary outcome: Serologically-confirmed influenza infection (symptomatic or asymptomatic)


Minimum age: 18 Years. Maximum age: 65 Years. Gender(s): Both.


Inclusion Criteria:

- Age 18 -65

- Have the ability to provide informed consent

- If a woman of child-bearing potential, willing to use contraception for the period of

the trial Exclusion Criteria:

- Acute influenza-like illness at screening

- History of psoriasis, porphyria cutanea tarda, epilepsy, myasthenia gravis, myopathy

of any cause, cardiac arrhythmias, or serious hepatic or renal disease

- Pregnancy or breast feeding

- Current use of medication with known serious hepatotoxic effects

- Current use of medication with known serious interaction with CQ: amiodarone,

anticonvulsants, ciclosporin, digoxin, mefloquine, moxifloxacin

- Current severe depression (as indicated by current use of antidepressant medication)

- Known serious retinal disease

- Current or recent (within the past 30 days) participation in any other clinical

intervention trial.

- Known G6PD deficiency

- Vaccination for influenza (seasonal or H1N1 strain) within the 3 months prior to


Locations and Contacts

Investigational Medicines Unit, National University Hospital, Singapore 119074, Singapore
Additional Information

Starting date: November 2009
Last updated: February 28, 2010

Page last updated: August 20, 2015

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