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Protective Effect of Propofol Against Hemolysis in Patients Submitted to Gastroplasty

Information source: Centro Medico Campinas
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Hemolysis

Intervention: Propofol (Drug)

Phase: N/A

Status: Active, not recruiting

Sponsored by: Centro Medico Campinas

Official(s) and/or principal investigator(s):
Ricardo F Simoni, MD, Principal Investigator, Affiliation: Fundação Centro Médico de Campinas

Summary

The purpose of this study is to determine if propofol could protect erythrocytes by directly scavenging free radicals from the blood current and increasing resistance of their cell membranes in patients submitted to gastroplasty.

Clinical Details

Official title: Protective Effect of Propofol Against Hemolysis in Patients Submitted to Gastroplasty

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: Count erythrocytes

Secondary outcome: Bilirubins(direct and indirect)

Eligibility

Minimum age: 18 Years. Maximum age: 65 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- patients between BMI 40-50 kg/m2

Exclusion Criteria:

- patients with BMI under 40 kg/m2 and over 50 kg/m2

- alcohol users

- illicit-drug users

- patients in regular use of anti-depressants, proton bomb inhibitors or calcium canal

blockers

- patients transfused either recently, during the intra-operative period or within 10

hours post-operative

- patients previously known to be hypersensitive to any drug that is used during the

study

- patients with any psychiatric disorder or dementia

Locations and Contacts

Fundação Centro Médico de Campinas, Campinas, São Paulo 13084-000, Brazil
Additional Information

Starting date: November 2008
Last updated: November 4, 2009

Page last updated: August 20, 2015

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