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Study of the Intraocular Pressure (IOP)-Lowering Efficacy of Azopt 1.0% Compared to Timolol 0.5% in Patients With Glaucoma or Ocular Hypertension

Information source: Alcon Research
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Primary Open Angle Glaucoma; Ocular Hypertension

Intervention: brinzolamide 1.0% (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: Alcon Research

Official(s) and/or principal investigator(s):
John Liu, PhD, Principal Investigator, Affiliation: University of California, San Diego

Summary

This is a multiple-dose study of the IOP-lowering efficacy of Azopt (brinzolamide) 1. 0% compared to timolol 0. 5% when added to a prostaglandin analogue (PGA) as adjunctive therapy over a 24 hour period in patients with glaucoma or ocular hypertension.

Clinical Details

Official title: A Multiple-Dose Study of the IOP-Lowering Efficacy of Azopt 1.0% Compared to Timolol 0.5% When Added to a PGA as Adjunctive Therapy Over a 24 Hour Period in Patients With Glaucoma or Ocular Hypertension

Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Primary outcome: IOP-lowering at 8 and 16 weeks

Secondary outcome: Safety throughout the 16 weeks of the study

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Primary open angle glaucoma or ocular hypertension patients

Exclusion Criteria:

- Women of childbearing potential

- History of bronchial asthma, or severe chronic obstructive pulmonary disease

- Presence of acute glaucoma

Locations and Contacts

San Diego, California, United States
Additional Information

Starting date: September 2006
Last updated: April 7, 2012

Page last updated: August 20, 2015

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