To evaluate the safety and tolerability of two different doses of Consensus Interferon-Alpha
and Interferon Gamma-1b with or without ribavirin in patients with chronic hepatitis C who
are non-responders to PEG-IFN-a 2a or PEG-IFN-a 2b plus ribavirin.
Inclusion Criteria:
1. Signed, written, informed consent from the patient or legal representative before any
study-specific procedures are performed
2. Male or female 18 years of age or older
3. Chronic hepatitis C infection based on history of positive serum anti-HCV antibody
and/or HCV RNA
4. Patients must have documented failure to respond to past treatment with PEG-Intron or
Pegasys plus RBV.
5. Liver biopsy within 3 years of screening documenting chronic liver disease consistent
with chronic hepatitis C
Exclusion Criteria:
1. Patients with any history of decompensated liver disease including but not restricted
to portal hypertension as manifested by gastroesophageal varices, variceal bleeding,
ascites, or encephalopathy
2. Specific laboratory abnormalities at Screening
3. Patients who were HCV RNA negative during prior pegylated interferon plus ribavirin
treatment, but who relapsed during follow-up
4. Recent depression or psychiatric disorders
5. Known HIV infection or positive HIV antibody test at Screening
6. Chronic hepatitis B infection or positive hepatitis B surface antigen (HBsAg) at
Screening
7. Unstable or uncontrolled thyroid disease
8. Presence or history of non-HCV chronic liver disease
9. History of unstable or deteriorating cardiovascular or cerebrovascular disease within
6 months prior to Screening
10. Current or history of neurologic disorder within a specified time frame
11. A disease known to cause significant alteration in immunologic function including
hematological malignancy, sarcoidosis or autoimmune disorder (e. g. rheumatoid
arthritis, systemic lupus erythematosis, leukemia, lymphoma, autoimmune thyroid
disease, scleroderma, psoriasis, inflammatory bowel disease, multiple sclerosis etc.)
12. History of major organ transplantation (i. e., liver, kidney, lung, or heart) with an
existing functional graft, including bone marrow transplant or stem cell transplant
13. Concurrent therapy with immunosuppressive drugs or cytotoxic agents such as
cyclosporine, azathioprine, chronic systemic corticosteroids, or chemotherapeutic
agent(s) (e. g., cyclophosphamide, methotrexate, or cancer chemotherapy) or radiation
therapy
14. Pregnant or lactating women
15. Liver biopsy within the past three years documenting cirrhosis
