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Intravenous Immunoglobulin (IVIG) Versus Plasma Exchange (PE) for Ventilated Children With Guillain Barre Syndrome (GBS)

Information source: Mansoura University Children Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Guillain Barre Syndrome

Intervention: IVIG (Drug); Plasma Exchange (Procedure)

Phase: N/A

Status: Completed

Sponsored by: Mansoura University Children Hospital

Official(s) and/or principal investigator(s):
Mohammed A El-Bayoumi, MD, FRCPCH, Principal Investigator, Affiliation: Head of PICU, Mansoura University Children Hospital


Comparing whether intravenous immune globulin or plasma exchange is superior in treating mechanically ventilated children with Guillain Barre syndrome.

Clinical Details

Official title: Comparison of Intravenous Immunoglobulin and Plasma Exchange in Treatment of Mechanically Ventilated Children With Guillain Barre Syndrome. A Randomized Study.

Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Duration of mechanical ventilation

Secondary outcome:

PICU stay

Ability to walk

Detailed description: Children with Guillain Barre syndrome (GBS) admitted to PICU at Mansoura University Children Hospital, Mansoura, Egypt with the need for mechanical ventilation were prospectively enrolled in the study. Cases were diagnosed according to clinical criteria. The decisions to initiate, wean and terminate mechanical ventilation were made independently by the attending consultant in accordance with the unit guidelines. Outcome variables measured were duration of mechanical ventilation, length of PICU stay and ability to walk unaided 4 weeks after PICU discharge.


Minimum age: 1 Month. Maximum age: 18 Months. Gender(s): Both.


Inclusion Criteria:

- Age: children from 1 month - 18 years old

- Clinical diagnosis of Guillain Barre syndrome

- Requirement of mechanical ventilation

Exclusion Criteria:

- Need for mechanical ventilation beyond 14 days from disease onset

- Child receiving IVIG or PE prior to enrollment

Locations and Contacts

Mansoura University Children Hospital, Mansoura, Dakahlia, Egypt
Additional Information

Starting date: January 2007
Last updated: March 1, 2011

Page last updated: August 23, 2015

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