Intravenous Immunoglobulin (IVIG) Versus Plasma Exchange (PE) for Ventilated Children With Guillain Barre Syndrome (GBS)
Information source: Mansoura University Children Hospital
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Guillain Barre Syndrome
Intervention: IVIG (Drug); Plasma Exchange (Procedure)
Phase: N/A
Status: Completed
Sponsored by: Mansoura University Children Hospital Official(s) and/or principal investigator(s): Mohammed A El-Bayoumi, MD, FRCPCH, Principal Investigator, Affiliation: Head of PICU, Mansoura University Children Hospital
Summary
Comparing whether intravenous immune globulin or plasma exchange is superior in treating
mechanically ventilated children with Guillain Barre syndrome.
Clinical Details
Official title: Comparison of Intravenous Immunoglobulin and Plasma Exchange in Treatment of Mechanically Ventilated Children With Guillain Barre Syndrome. A Randomized Study.
Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Primary outcome: Duration of mechanical ventilation
Secondary outcome: PICU stayAbility to walk
Detailed description:
Children with Guillain Barre syndrome (GBS) admitted to PICU at Mansoura University Children
Hospital, Mansoura, Egypt with the need for mechanical ventilation were prospectively
enrolled in the study.
Cases were diagnosed according to clinical criteria. The decisions to initiate, wean and
terminate mechanical ventilation were made independently by the attending consultant in
accordance with the unit guidelines.
Outcome variables measured were duration of mechanical ventilation, length of PICU stay and
ability to walk unaided 4 weeks after PICU discharge.
Eligibility
Minimum age: 1 Month.
Maximum age: 18 Months.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Age: children from 1 month - 18 years old
- Clinical diagnosis of Guillain Barre syndrome
- Requirement of mechanical ventilation
Exclusion Criteria:
- Need for mechanical ventilation beyond 14 days from disease onset
- Child receiving IVIG or PE prior to enrollment
Locations and Contacts
Mansoura University Children Hospital, Mansoura, Dakahlia, Egypt
Additional Information
Starting date: January 2007
Last updated: March 1, 2011
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