DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more



A Study to Test Safety and Efficacy of IMGN901 in Combination With Carboplatin/Etoposide in Patients With Advanced Solid Tumors and Extensive Stage Small Cell Lung Cancer

Information source: ImmunoGen, Inc.
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Small Cell Lung Cancer

Intervention: IMGN901 (Drug); Carboplatin and Etoposide (Drug)

Phase: Phase 1/Phase 2

Status: Active, not recruiting

Sponsored by: ImmunoGen, Inc.

Summary

The purpose of this study is to test safety and efficacy of this combination treatment (IMGN901, carboplatin and etoposide) in patients with solid tumors and extensive stage small cell lung cancer.

Clinical Details

Official title: A Phase 1/2 Study to Assess the Safety and Efficacy of Lorvotuzumab Mertansine in Combination With Carboplatin/Etoposide in Patients With Advanced Solid Tumors Including Extensive Stage Small Cell Lung Cancer

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Occurrence of Dose Limiting Toxicities (DLT)

Secondary outcome: Type and frequency of Adverse Events (AEs) and Serious Adverse Events (SAEs)

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Patients must be 18 years old

- Patients must have been diagnosed with small-cell lung cancer (SCLC) and extensive

disease

- ECOG performance status of 0, 1, or 2

- No prior systemic chemotherapy for the treatment of SCLC

Exclusion Criteria:

- Pregnant or lactating females

Locations and Contacts

Hospital de la Santa Creu y Sand Pau, Barcelona 08041, Spain

Hospital Vall d'Hebron, Barcelona 08035, Spain

Hospital Universitario, Madrid 28222, Spain

Hospital Universitario 12 de Octubre, Madrid 28041, Spain

Hospital Universitario Virgen del Rocio, Sevilla 41013, Spain

Royal Marsden, London, London SW3 6JJ, United Kingdom

Arizona Cancer Center @ UMC North, Tucson, Arizona 85719, United States

Corporacio Sanitaria Parc Tauli, Sabadell, Barcelona, Spain

UCLA Oncology Center, Los Angeles, California 90095, United States

St. Joseph's Hospital, Orange, California 92868, United States

UCLA Hematology, Pasadena, California 91105, United States

UCLA Oncology Clinic, Santa Monica, California 90404, United States

UCLA Santa Clarita Valley Cancer Center, Valencia, California 91355, United States

UCLA Oncology Center, Westlake Village, California 91361, United States

Yale Medical Center, New Haven, Connecticut 06510, United States

Sibley Memorial Hospital, Washington, District of Columbia 20016, United States

Royal Sussex Hospital, Brighton, East Sussex BN2 5BE, United Kingdom

University College of London, London, England NM12BU, United Kingdom

Holy Cross Hospital Bienes Comprehensive Cancer Center, Fort Lauderdale, Florida 33308, United States

University of Florida, Gainesville, Florida 32608, United States

The Christie Hospital, Withington, Manchester M20 4BX, United Kingdom

Anne Arundel Medical Center, Annapolis, Maryland 21401, United States

Bayview Medical Center, Baltimore, Maryland 21224, United States

Greater Baltimore Medical Center, Baltimore, Maryland 21204, United States

Johns Hopkins University, Baltimore, Maryland 21287, United States

Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, United States

Dana Farber Cancer Institute, Boston, Massachusetts 02215, United States

Massachusetts General Hospital, Boston, Massachusetts 02114-2696, United States

Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, United States

Johnson Therurer Cancer Center at Hackensack, Hackensack, New Jersey 07601, United States

University Hospitals of Cleveland, Cleveland, Ohio 44106, United States

Oklahoma University, Oklahoma City, Oklahoma 73104-5417, United States

Juravinski Cancer Center, Hamilton, Ontario L8V 5C2, Canada

Oregon Health and Science University, Portland, Oregon 97239, United States

UPMC Cancer Centers East, Oxford Drive, Monroeville, Pennsylvania 15146, United States

Univeristy of Pittsburg Medical Center, Pittsburgh, Pennsylvania 15232, United States

UPMC Cancer Center at UPMC Passavant (HOA), Pittsburg, Pennsylvania 15237, United States

UPMC Cancer Center St. Margaret, Pittsburg, Pennsylvania 15215, United States

Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada

Montreal General Hospital, Montreal, Quebec H3G 1A4, Canada

Royal Victoria, Montreal, Quebec QC H3G, Canada

St. Mary's Hospital, Montreal, Quebec H3T 1M5, Canada

South Carolina Oncology Associates, Columbia, South Carolina 29210, United States

Royal Marsden, Sutton, Downs Road, Sutton SM2 5PT, United Kingdom

University of Tennessee Medical Center Cancer Institute, Knoxville, Tennessee 37920, United States

Sarah Cannon Research Institute, Nashville, Tennessee 37203, United States

UTHSC at San Antonio, San Antonio, Texas 78229, United States

Northwest Medical Specialties, Tacoma, Washington 98405, United States

Additional Information

Starting date: November 2010
Last updated: January 8, 2015

Page last updated: August 23, 2015

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017