Observational study to compare the treatment in neutropenic patients after allogenic blood
stem cell transplantation, with meropenem or meropenem plus glycopeptide.
The study will be done in two consecutive cohorts of patients. First cohort: meropenem 1g/8h
ev Second cohort: meropenem 1g/8h and glycopeptide (vancomycin 1g/12 h or teicoplanin 400
mg/24h)
Sanz Miguel Angel, Dr, Phone: 34. 96 197 30 57, Email: sanz_mig@gva.es
Hospital de la Ribera, Alzira, Spain; Recruiting
Hospital Francesc de Borja, Gandia, Spain; Recruiting
Hospital San Millan, Cáceres, Spain; Recruiting
Hospital Virgen de Las Nieves, Granada, Spain; Recruiting
Hospital Rio Hortega, Valladolid, Spain; Recruiting
Basurtuko Ospitalea, Basurto, Spain; Recruiting
Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain; Recruiting
Hospital de Cruces, Bilbao, Spain; Recruiting
Hospital G. de Alicante, Alicante, Spain; Recruiting
Hospital Clínico Universitario de Valencia, Valencia, Spain; Recruiting
Hospital Universitario Salamanca, Salamanca, Spain; Recruiting
Complexo H. Xeral-Calde, Lugo, Spain; Recruiting
Hospital Clínico San Carlos, Madrid, Spain; Recruiting
Hospital U. La Fe (H. Infantil), Valencia, Spain; Recruiting
Hospital C. de Barcelona, Barcelona, Spain; Recruiting
Hospital Sant Pau, Barcelona, Spain; Recruiting
Hospital U. Vall D'Hebron, Barcelona, Spain; Recruiting
Hospital Durant y Reynals, Barcelona, Spain; Recruiting
Hospital del Mar, Barcelona, Spain; Recruiting
Hospital General de Castellón, Castellón, Spain; Recruiting
Hospital Puerta del Mar, Cádiz, Spain; Recruiting
Hospital Doctor Josep Trueta, Girona, Spain; Recruiting
H. Xeral de Galicia, La Coruña, Spain; Recruiting
Hospital Juan Canalejo, La Coruña, Spain; Recruiting
Hospital La Princesa, Madrid, Spain; Recruiting
Hospital Gregorio Marañón, Madrid, Spain; Recruiting
Hospital Ramón y Cajal, Madrid, Spain; Recruiting
Clínica Puerta de Hierro, Madrid, Spain; Recruiting
Hospital La Paz, Madrid, Spain; Recruiting
Hospital 12 de Octubre, Madrid, Spain; Recruiting
Hospital U. Virgen de la Arrixaca, Murcia, Spain; Recruiting
Hospital General de Murcia, Murcia, Spain; Recruiting
Hospital Reina Sofia, Murcia, Spain; Recruiting
Hospital Carlos Haya, Málaga, Spain; Recruiting
H. Universitario Virgen de la Victoria, Málaga, Spain; Recruiting
Hospital Aránzazu, Santander, Spain; Recruiting
Hospital U. Marques de Valdecilla, Santander, Spain; Recruiting
Hospital Vírgen del Rocío, Sevilla, Spain; Recruiting
Hospital de Tarragona "Joan XXIII", Tarragona, Spain; Recruiting
Hospital U. La Fe, Valencia, Spain; Recruiting
Hospital General U. de Valencia, Valencia, Spain; Recruiting
Hospital Arnao de Vilanova, Valencia, Spain; Recruiting
Instituto Valenciano de Oncología, Valencia, Spain; Recruiting
Hospital Dr. Peset, Valencia, Spain; Recruiting
Hospital C. de Valladolid, Valladolid, Spain; Recruiting
Hospital do Meixoeiro, Vigo, Spain; Recruiting
Hospital C.U. De Zaragoza, Zaragoza, Spain; Recruiting
Miguel Servet, Zaragoza, Spain; Recruiting
Hospital Central de Asturias, Oviedo, Asturias, Spain; Recruiting
Hospital Son Dureta, Palma de Mallorca, Balears, Spain; Recruiting
Hospital U. Germans Trias i Pujol, Badalona, Barcelona, Spain; Recruiting
Hospital General de Manresa, Manresa, Barcelona, Spain; Recruiting
Hospital Niño Jesus, Sabadell, Barcelona, Spain; Recruiting
Hospital Mutua Tarrasa, Terrassa, Barcelona, Spain; Recruiting
Hospital Universitario de Canarias, Tenerife, Canarias, Spain; Recruiting
Hospital Materno-Infantil de Las Palmas, Las Palmas de Gran Canaria, Canarias, Spain; Recruiting
Hospital Ntra Sra del Pino/Sabinal, las Palmas de Gran Canaria, Canarias, Spain; Recruiting
Hospital Insular de Las Palmas, Las palmas de Gran Canaria, Canarias, Spain; Recruiting
Hospital Virgen Blanca, Leon, León, Spain; Recruiting
Hospital Principe de Asturias, Alcalá de Henares, Madrid, Spain; Recruiting
Hospital Severo Ochoa, Leganes, Madrid, Spain; Recruiting
Hospital Verge de la Cinta, Tortosa, Tarragona, Spain; Recruiting
Hospital Luis Alcañiz de Xátiva, Xativa, Valencia, Spain; Recruiting
Hospital de Sagunto, Sagunto, Valencia, Spain; Recruiting
Cometta A, Glauser MP. Empiric antibiotic monotherapy with carbapenems in febrile neutropenia: a review. J Chemother. 1996 Oct;8(5):375-81. Review.
Klastersky J. Current attitudes for therapy of febrile neutropenia with consideration to cost-effectiveness. Curr Opin Oncol. 1998 Jul;10(4):284-90.
Hughes WT, Armstrong D, Bodey GP, Bow EJ, Brown AE, Calandra T, Feld R, Pizzo PA, Rolston KV, Shenep JL, Young LS. 2002 guidelines for the use of antimicrobial agents in neutropenic patients with cancer. Clin Infect Dis. 2002 Mar 15;34(6):730-51. Epub 2002 Feb 13. No abstract available.
Koya R, Andersen J, Fernandez H, Goodman M, Spector N, Smith R, Hanlon J, Cassileth PA. Analysis of the value of empiric vancomycin administration in febrile neutropenia occurring after autologous peripheral blood stem cell transplants. Bone Marrow Transplant. 1998 May;21(9):923-6.
Celebi H, Akan H, Akcaglayan E, Ustun C, Arat M. Febrile neutropenia in allogeneic and autologous peripheral blood stem cell transplantation and conventional chemotherapy for malignancies. Bone Marrow Transplant. 2000 Jul;26(2):211-4.
Smith TL, Pearson ML, Wilcox KR, Cruz C, Lancaster MV, Robinson-Dunn B, Tenover FC, Zervos MJ, Band JD, White E, Jarvis WR. Emergence of vancomycin resistance in Staphylococcus aureus. Glycopeptide-Intermediate Staphylococcus aureus Working Group. N Engl J Med. 1999 Feb 18;340(7):493-501.
Dompeling EC, Donnelly JP, Deresinski SC, Feld R, Lane-Allman EF, De Pauw BE. Early identification of neutropenic patients at risk of grampositive bacteraemia and the impact of empirical administration of vancomycin. Eur J Cancer. 1996 Jul;32A(8):1332-9.
