Timing of Prophylactic Antibiotics for Cesarean Sections

Condition(s) targeted: Endometritis; Wound Infection

Intervention: Cefazolin (Drug)

Phase: N/A

Status: Completed

Sponsored by: Medical University of South Carolina

Official(s) and/or principal investigator(s):
Scott A Sullivan, MD, Principal Investigator, Affiliation: Medical University of South Carolina

This is a randomized, double-blinded placebo controlled trial of cefazolin timing before cesarean section fo infection prophylaxis. Subjects are randomized to cefazolin either 30 minutes prior to skin incision or at time of cord-clamping. Primary outcome is infectious morbidity including wound infections and endometritis.

Official title: A Randomized, Double-Blind, Placebo Controlled Trial of Cefazolin Given Either 30 Minutes Prior to Cesarean Section or at Cord Clamping

Study design: Prevention, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Safety/Efficacy Study

Primary outcome: Combined infectious morbidity - endometritis + wound infection

Secondary outcome:

Neonatal sepsis

Allergic reactions

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Female.

Criteria:

Inclusion Criteria:

Pregnant 24-43 weeks gestation > 18 years old Requiring cesarean section -

Exclusion Criteria:

Receiving antibiotics < 18 years old Allergy to cefazolin

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Medical University of South Carolina, Charleston, South Carolina 29425, United States

Starting date: January 2003
Ending date: January 2006
Last updated: September 26, 2007