Analgetic Effect of Preoperative Pregabalin in Patients Undergoing Nephrectomy
Information source: Medical University of Graz
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Postoperative Pain
Intervention: Pregabalin (Drug); Placebo (Drug)
Phase: Phase 3
Status: Completed
Sponsored by: Medical University of Graz Official(s) and/or principal investigator(s): Andreas Sandner-Kiesling, MD, Study Chair, Affiliation: Medical University of Graz Helmar Bornemann-Cimenti, MD, DSc, Principal Investigator, Affiliation: Graz Medical University
Summary
Pregabalin 300mg or placebo are administered 1 hour preoperatively in patients undergoing
elective nephrectomy. Postoperatively, patients receive a patient controlled analgesia
device for self delivering opioids. Morphine consumption in the first 48 hours is
documented.
Hyperalgesia is measured by von-Frey-Filaments.
Clinical Details
Official title: Effect of Preoperative Pregabalin Administration on the Postoperative Opioid Consumption in Patients Undergoing Nephrectomy
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
Primary outcome: postoperative opioid consumption
Eligibility
Minimum age: 18 Years.
Maximum age: 70 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- patients undergoing elective nephrectomy
Exclusion Criteria:
- contraindication against pregabalin
- creatinine > 2. 0 mg/dl
- GGT >165, AST >105, ALT >135
- peptic Ulcus
- haemorrhagic diathesis
- angina pectoris, myocardial infarction
- stroke
- bronchial asthma
- opioid abuse
Locations and Contacts
Medical University of Graz, Graz 8036, Austria
Additional Information
Medical University of Graz
Starting date: April 2009
Last updated: May 26, 2011
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