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The Effect of Byetta and Symlin on Post-meal Meal Blood Sugar Levels in Children With Type 2 Diabetes

Information source: Baylor College of Medicine
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Type 2 Diabetes

Intervention: Byetta (exenatide) (Drug); Symlin (pramlintide) (Drug)

Phase: Phase 4

Status: Recruiting

Sponsored by: Baylor College of Medicine

Official(s) and/or principal investigator(s):
LUISA M RODRIGUEZ, MD, Principal Investigator, Affiliation: Baylor College of Medicine

Overall contact:
Kathy Shippy, RN, Phone: 832-822-3768, Email: kshippy@bcm.edu

Summary

The purpose of this study is to see if giving study drugs before a meal may lower blood sugars after the meal. An improvement in blood sugar control may prevent long-term problems of diabetes.

Clinical Details

Official title: The Effect of the Glucagon Suppressors Pramlintide and Exenatide on Postprandial Glucose Metabolism in Children With Type 2 Diabetes Mellitus

Study design: Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment

Primary outcome: Glucose

Secondary outcome:

glucagon

gastric emptying

pramlintide concentrations

exenatide concentrations

Detailed description: A large study in people with type 2 diabetes (T2DM) showed that lowering blood sugars stopped or delayed the occurrence of health problems. As a result of the study, treatment should try to control blood sugars as near to normal as safely possible. In people without diabetes, the "after meal" blood sugar level is very carefully controlled by several hormones. Insulin (the hormone that lowers blood sugar) and glucagon (hormone that raises blood sugar) play a key role in keeping this careful balance. Also, we now know of 2 new substances made by the body called amylin and GLP-1 that also help with this careful balance. Amylin is made in the pancreas. GLP-1 is made in the gut. We know that both amylin and GLP-1 are abnormal in people with diabetes. There are two medicines that may help to control after meal blood sugars from going too high. The medicines are called Symlin (pramlintide) and Byetta (exenatide). Symlin works like amylin. Byetta works like GLP-1. Both medications are very similar in the ways that they work to control blood sugars. Both medicines help to keep glucagon lower after a meal. They both also help the stomach to digest food more slowly so the blood sugar does not go up too fast after eating. They also help to control how much hunger a person may have before meals. This may help a person to eat less and possibly lose weight. Byetta also seems to help islet cells (cells that make insulin) make more insulin. Byetta and Symlin are FDA approved for use in adults with T2DM. We want to study these drugs in children with T2DM.

Eligibility

Minimum age: 12 Years. Maximum age: 21 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Children with Type 2 Diabetes,

- Between the ages of 12-21 years,

- Tanner stage 4-5 for pubertal development,

- Menstruating females must have a negative urine pregnancy test for inclusion,

- Must have T2DM for at least 6 months,

- History of negative anti-glutamic acid decarboxylase (GAD) -65 and anti-islet cell

antibodies,

- HbA1c < 8. 5% and on a stable dose of an oral hypoglycemic agent (with or without

insulin) over the last 2 months, or well controlled on diet. Exclusion Criteria:

- A history of a chronic disease other than diabetes (leukemia, asthma, inflammatory

bowel disease, cystic fibrosis, juvenile rheumatoid arthritis, dyslipidemia, cholelithiasis etc),

- BMI> 40 kg/m2,

- Weight of < 60 kg,

- Female with menstrual irregularities,

- Allergy to local anesthetics (ELAMAX Cream, Ethyl Chloride),

- Evidence or history of chemical abuse,

- Anemia (age specific normal range for hemoglobin will be used),

- Elevated liver enzymes (defined as more than 3 times the upper limit of the normal

range for age),

- Elevated BUN or creatinine (defined as more than 3 times the upper limit of the

normal range for age),

- Use of medications that may increase the blood sugars and admission to the hospital

for diabetes related problems over the last 6 months.

Locations and Contacts

Kathy Shippy, RN, Phone: 832-822-3768, Email: kshippy@bcm.edu

Baylor College of Medicine, Houston, Texas 77030, United States; Recruiting
MOREY W HAYMOND, MD, Sub-Investigator
AGNETA L SUNEHAG, MD, Sub-Investigator
RUBINA A HEPTULLA, MD, Sub-Investigator
SIRIPOOM V MCKAY, MD, Sub-Investigator
Additional Information

Starting date: July 2009
Last updated: December 9, 2010

Page last updated: August 23, 2015

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