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Evaluation of the Utility of Minocycline as an Anti-Inflammatory Agent in the Treatment of Asthma

Information source: State University of New York - Downstate Medical Center
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Asthma

Intervention: minocycline (Drug)

Phase: Phase 2

Status: Active, not recruiting

Sponsored by: State University of New York - Downstate Medical Center

Official(s) and/or principal investigator(s):
Rauno Joks, MD, Principal Investigator, Affiliation: State University of New York - Downstate Medical Center

Summary

Trial of effects of minocycline as "add-on" therapy to adults with asthma with a history of requiring at least one episode of oral steroid therapy to control the disease.

Clinical Details

Official title: Evaluation of the Utility of Minocycline as an Anti-Inflammatory Agent in the Treatment of Asthma

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Primary outcome: Decrease in oral steroid therapy requirements.

Secondary outcome:

improvement in symptoms scores

improvement in spirometric outcomes

improvement in morning and evening peak flow

decrease in rescue inhaler usage

Detailed description: This is a double-blind, placebo-controlled crossover study of adult asthmatics given minocycline 150 mg po BID or placebo as add-on therapy for eight weeks each. Each eight week arm is separated by a four week wash-out. Spirometry is performed at the baseline and end of each arm. Daily symptoms scores, peak flow rates, and oral steroid requirements are recorded. A standardized asthma quality of life symptoms assessment is made every four weeks (AQLQ, Juniper).

Eligibility

Minimum age: 18 Years. Maximum age: 75 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Adult asthmatics

- History of or current use of oral steroids to control symptoms

Exclusion Criteria:

- Pregnant women

Locations and Contacts

SUNY Downstate Medical Center, Brooklyn, New York 11203, United States
Additional Information

Starting date: June 1996
Last updated: April 4, 2007

Page last updated: August 23, 2015

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