Evaluation of the Utility of Minocycline as an Anti-Inflammatory Agent in the Treatment of Asthma
Information source: State University of New York - Downstate Medical Center
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Asthma
Intervention: minocycline (Drug)
Phase: Phase 2
Status: Active, not recruiting
Sponsored by: State University of New York - Downstate Medical Center Official(s) and/or principal investigator(s): Rauno Joks, MD, Principal Investigator, Affiliation: State University of New York - Downstate Medical Center
Summary
Trial of effects of minocycline as "add-on" therapy to adults with asthma with a history of
requiring at least one episode of oral steroid therapy to control the disease.
Clinical Details
Official title: Evaluation of the Utility of Minocycline as an Anti-Inflammatory Agent in the Treatment of Asthma
Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double-Blind, Primary Purpose: Treatment
Primary outcome: Decrease in oral steroid therapy requirements.
Secondary outcome: improvement in symptoms scoresimprovement in spirometric outcomes improvement in morning and evening peak flow decrease in rescue inhaler usage
Detailed description:
This is a double-blind, placebo-controlled crossover study of adult asthmatics given
minocycline 150 mg po BID or placebo as add-on therapy for eight weeks each. Each eight week
arm is separated by a four week wash-out. Spirometry is performed at the baseline and end of
each arm. Daily symptoms scores, peak flow rates, and oral steroid requirements are
recorded. A standardized asthma quality of life symptoms assessment is made every four weeks
(AQLQ, Juniper).
Eligibility
Minimum age: 18 Years.
Maximum age: 75 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Adult asthmatics
- History of or current use of oral steroids to control symptoms
Exclusion Criteria:
- Pregnant women
Locations and Contacts
SUNY Downstate Medical Center, Brooklyn, New York 11203, United States
Additional Information
Starting date: June 1996
Last updated: April 4, 2007
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