Relationship Between D2 Receptors SPECT and the Apomorphine Test in Patients With OH Dependence (ALC-DRD2-APO)
Information source: Hospital Universitari Vall d'Hebron Research Institute
Information obtained from ClinicalTrials.gov on February 07, 2013
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Alcoholism
Intervention: apomorphine (Drug); [(123)I] iodobenzamide (Drug)
Phase: Phase 2
Status: Recruiting
Sponsored by: Hospital Universitari Vall d'Hebron Research Institute Official(s) and/or principal investigator(s):
Miquel Casas, Prof, Principal Investigator, Affiliation: Psychiatry Service, Hospital Universitari Vall d'Hebron
Overall contact:
Miquel Casas, Prof., Email: mcasas@vhebron.net
Summary
OH dependence is associated with DA receptor changes. Both, the apomorphine test and the
D2Rec SPECt are usefull for monitoring DA receptor status. We aimed at studying whether DA
receptor hypofunction, assessed by means of the apomorphine test and the D2Rec SPECT, is a
marker of relapse in detoxified OH dependents patients.
Clinical Details
Official title: Relationship Between D2 Receptors SPECT and the Apomorphine Test in Patients With OH Dependence: Predictive Value for Relapse
Study design: Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
Primary outcome: To detertmine the agreement rate of the dopaminergic sensibility assessed by two different techiniques: the apomorphine test and and IBZM SPECT.
Eligibility
Minimum age: 25 Years.
Maximum age: 60 Years.
Gender(s): Male.
Criteria:
Inclusion Criteria:
- alcohol dependence
- alcohol dependence length at least 8 years.
- male
- age 25 - 60 years
Exclusion Criteria:
- other drug dependence (except nicotine dependence)
- another major axis I psychiatric diagnosis
- comorbid neurological disorder
- comorbid cardiovascular disorder
- comorbid metabolic disorder
- brain injury
- apomorphine allergy
- iode allergy
- diazepam allergy
Locations and Contacts
Miquel Casas, Prof., Email: mcasas@vhebron.net
Psychiatry Service, Hospital Universitari Vall d'Hebron, Barcelona, Catalonia 08036, Spain; Recruiting
Miquel Casas, Prof, Email: mcasas@vhebron.net
Xavier Castells, Email: xcc@icf.uab.cat
Miquel Casas, Prof, Principal Investigator
Additional Information
Starting date: January 2007
Last updated: April 28, 2009
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